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Yale School of Medicine

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Treating Brain Tumor by Changing Cell Division Pattern

Brain Tumors

A major challenge in treating malignant brain tumors is why killing the vast majority of cancer cells does not lead to a cure. The apparent similarity between the ability of cancer cells to proliferate uncontrollably and that of the stem cells to continuously replenish themselves (self-renew) has led to the notion that cancers are diseases of stem cells and that a few cancer stem cells are sufficient to form new tumors to cause relapse and prevent cure.

Elucidating the Initiation Mechanism of the Fanconi Anemia Pathway of DNA Damage Repair

General Pediatric Cancer

Fanconi anemia (FA) is a childhood disease characterized by multiple devastating symptoms, which include bone marrow failure leading to aplastic anemia, congenital abnormalities, and a high incidence of cancer. Although recent medical advances have increased the life expectancy for FA patients, they often succumb to tumor malignancies before reaching adulthood. Therefore, research into the cellular and molecular basis of FA-associated cancer is urgently needed.

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Featured Hero

Chris Ramirez

Chris loves baseball – he has a history of playing for his high school team and is a longtime fan of the San Francisco Giants. However, when he was in high school, Chris began having strange symptoms. Today, Chris is a three-time survivor of glioblastoma.
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