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Targeting Metabolic Vulnerabilities in ETP-ALL

Institution: 
Columbia University
Researcher(s): 
Adolfo A. Ferrando, MD/PhD
Grant Type: 
Innovation Grants
Year Awarded: 
2017
Type of Childhood Cancer: 
Leukemia
Project Description: 

Background
Early T cell precursor leukemia (ETP ALL) is an aggressive hematologic malignancy that requires treatment with intensified chemotherapy. Thus, further advances in the treatment of this disease require the development of effective and highly specific molecularly targeted anti-leukemic drugs. There is growing awareness that targeting the metabolic differences between tumor and normal cells holds promise as a novel anticancer strategy. 

Project Goal
This project seeks to unveil key metabolic factors required for proliferation and survival in ETP ALL. These studies will be instrumental for the development of novel targeted therapies for the treatment of this high-risk leukemia group.