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Functional Dissection of Oncogenic Enhancers in T-ALL

Institution: 
Columbia University
Researcher(s): 
Daniel Herranz, PhD
Grant Type: 
Young Investigator Grants
Year Awarded: 
2015
Type of Childhood Cancer: 
Leukemia, Acute Lymphoblastic Leukemia (ALL)
Project Description: 

Background

Following on the completion of the Human Genome Project and using innovative sequencing tools researchers are rapidly annotating the complete repertoire of genetic alterations in cancer. However most of these lesions are located in genomic "dark matter" outside of well-annotated genes.

 

Project Goal

In this research project we will develop state-of-the-art new tools to analyze the function of critical as yet un-annotated genomic sequences controlling the activity of MYC, a major cancer-driving gene.

These studies will shed light on the function and mechanisms of cancer-associated "dark matter" regions in the human genome opening new venues for the development of targeted therapies in human cancer.