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Cooperating Genes for inv16 Acute Myeloid Leukemia

University of Massachusetts Medical School
Lucio Castilla
Grant Type: 
Bridge Grants
Year Awarded: 
Type of Childhood Cancer: 
Acute Myeloid Leukemia (AML)
Project Description: 

Acute myeloid leukemia results from the accumulation of mutations that deregulate survival and differentiation of hematopoietic cells, and drive leukemia. We have studied the mechanism of leukemia development with oncogenic Ras and CBF mutations for over 20 years. In this application we are proposing studies in mice and leukemic cells to test the role of BIM inhibition as a target for leukemia, and to test RAS inhibitors as candidate therapies for these leukemias. These studies aim at establishing improved targeted therapies in childhood leukemia