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Neighborhood Factors, Acute Kidney Injury and Disparities in Pediatric Acute Myeloid Leukemia

Institution: 
Children's Hospital of Philadelphia
Researcher(s): 
Richard Aplenc, MD/PhD
Grant Type: 
Epidemiology Grants
Year Awarded: 
2018
Type of Childhood Cancer: 
Acute Myelogenous Leukemia (AML)
Project Description: 

Co-Investigators: Dr. Yimei Li, Dr. Tamara Miller & Dr. Marla Daves 

Background
Pediatric acute myeloid leukemia (AML) is the second most common pediatric leukemia and requires intensive treatment for a cure. These treatments have been less effective for racial and ethnic minority patients. Unfortunately, the reasons for this disparity in treatment outcomes are not known. Several investigative teams are working to understand these disparities in order to identify interventions that may decrease them. 

Project Goal
This application proposes to implement a new and potentially powerful way to build a cohort of patients with AML by automatically extracting data from the electronic medical records of four leading pediatric hospitals in the United States. Such a data extraction would enable a wide range of clinical epidemiology studies that may shed new light on the racial and ethnic disparities in pediatric AML. For this application, we propose to use this cohort-building method to study kidney damage during treatment for AML. We have chosen to study kidney damage based on prior data showing racial differences in the risk of kidney damage and the limited data on the causes of this disparity. Thus, this study will serve as a test case for the application of this new, cohort-building approach. In addition, if successful, this study may provide information about the risks of kidney damage during AML therapy that may identify changes that could decrease the risk of kidney damage. Additionally, this study may help identify modifiable causes for the disparities in kidney damage and AML outcomes in children.