The Aflac Cancer Center and Blood Disorders Service at Children’s Healthcare of Atlanta (CHOA) is one of the largest pediatric oncology programs in the United States and an important contributor to accrual on cooperative group clinical trials both for newly diagnosed and relapsed patients. In 2005, a total of 320 newly diagnosed patients were seen and a total of 73 stem cell transplants were performed. In addition, 92 relapsed patients were seen, unfortunately some of whom had recurred on more than one occasion.