The Interplay Between Histone Mutations and Replication Stress in Shaping Glioma Phenotypes
Pediatric high-grade gliomas are one of the most deadly cancers that occur in children. They are caused by mutations, or 'errors' in genes called histones.
This project will study how histone mutations interact with other genes in the cells to help them become a cancer cell. This includes understanding how histone mutations turn off the 'brakes' in normal cells, which normally stop cells from becoming cancer cells, while also turn on 'accelerators' that make cells divide faster than normal.
The goal of this project is to understand how histone mutations interact with other proteins in cells which help turn normal cells into cancer cells. We hope to understand this so that we can develop new treatments to reverse these changes.