Ewing sarcoma is a malignant cancer of bone and soft tissues that affects children, adolescents and young adults. Currently, combinations of intensive chemotherapy, surgery and radiation are only 70% effective for children with a localized tumor. If the tumors have spread to distant sites, fewer than 1/3 will survive. Additionally, children who survive face a lifelong risk of adverse health effects due to toxicity of therapy, such as secondary cancers, infertility, and significant heart damage. New therapeutic advances are needed that are more effective with fewer toxic side-effects.
