Ewing’s Sarcoma Family Tumors (ESFT) are aggressive tumors of bone and soft tissue which are mostly confined to childhood and adolescence. Even with intensified chemotherapy, approximately 40% of those diagnosed with ESFT will die of the disease. Despite intensive study into the molecular-level mechanisms of these tumors, remarkably little of use to patients has resulted. My lab has just published findings that demonstrate that a mechanism common to many adult cancers, also plays an important role in ESFT. This mechanism is called the Hedgehog-Gli pathway.