Children’s Hospital Los Angeles

Children’s Hospital Los Angeles

4650 Sunset Blvd.

Los Angeles, CA 90027

United States

Circulating Repetitive Element RNAs as an Osteosarcoma Marker

Osteosarcoma

Symptom Burden, Health-Related Quality of Life and Health Care Utilization Among Children Undergoing Hematopoietic Stem Cell Transplantation: Impact of Parent Sleep, Fatigue and Psychological Distress

General Pediatric Cancer

Background

Studies on the Growth-suppressive Mechanism of PID1 in Childhood Medulloblastoma

Medulloblastoma

Background

Due to the low cure rates and the many long-term effects of treatment for those cured the tumors of medulloblastoma take many lives each day. There is not enough good research and understanding of medulloblastoma biology to develop better therapies with less long term consequences.

Altered Cerebral Blood Flow after Pediatric Posterior Fossa Brain Tumor Treatment

Brain Tumors

Background

Single-cell RNA-seq Profiling of Transcriptional Transition States During Human Retinoblastoma

Retinoblastoma

Background

Retinoblastoma is a childhood ocular tumor initiated by the inactivation of the RB1 gene and subsequent loss of retinoblastoma protein (pRB). Although pRB loss is the key-initiating event, the molecular mechanisms controlling the transformation of a normal retinal cell into malignancy remain unclear.

Targeting PI3Kdelta in Childhood Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia (ALL)

The Samantha Hill Childhood Cancer Hero Reach Grant

Background

Although many children who are treated for acute lymphoblastic leukemia (ALL) are cured, a significant percentage are not, and when this happens the prognosis is grim. Therefore, we need new ideas for the treatment of relapsed ALL. Instead of targeting only the leukemia cells, we look at a wider target: the leukemia cells as well as the protective non-leukemia cells, which are located in the bone marrow and create a safe haven for ALL cells.