Childhood Cancer Research

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Children’s Hospital of Philadelphia

3401 Civic Center Boulevard
Philadelphia, PA 19104
United States

Alternative Splicing in the Pathogenesis of Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia (ALL)

Defining the Cell Surface Landscape of Diagnostic and Relapsed Neuroblastoma: Immunotherapeutic Target Identification

Neuroblastoma

Background


Neuroblastoma (NB) is a childhood cancer of the developing sympathetic nervous system that is often fatal. Despite intense therapy, the survival rate for high-risk NB remains less than 50% and relapsed NB is almost universally incurable. Utilizing one's immune system to fight cancer has shown remarkable results in both childhood and adult malignancies. Ideal immunotherapeutic targets are proteins expressed on the surface of cancerous cells, but absent on normal cells.

Identifying Targeted Therapeutics in Beckwith-Wiedemann Syndrome

Beckwith-Wiedemann Syndrome

Background

While some of the genetic changes that lead to Beckwith-Wiedemann Syndrome (BWS), a cancer predisposition disorder with a diagnosis rate of one in four in children, are understood, it is still unknown how those genetic changes lead to tumor development.

Identifying a Novel Therapeutic Combination Targeting MEK1/2 and KSR1 in Relapsed Neuroblastoma

Neuroblastoma

Background

Investigation of Socioeconomic Variables and Neutropenia Management on Pediatric Acute Myeloid Leukemia Outcomes

Acute Myeloid Leukemia (AML)

Background

Identification of LMO1 Binding Partners and Their Role in Neuroblastoma Tumorigenesis

Neuroblastoma

Background

Racial Disparities in Pediatric Acute Leukemia

Leukemia

Background

Preclinical Investigation of Entospletinib in Childhood B Cell Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia (ALL)

Background

Variation in Care and Outcomes in Pediatric Acute Leukemia - Amjad Shaikh (2017)

Leukemia

Background

Induction is the first phase of chemotherapy in pediatric acute leukemia. Mortality during induction within hospitals that contribute data to the Pediatric Health Information System (PHIS), an administrative database that includes 46 free-standing children’s hospitals, varies considerably. This variation suggests that there are center-level characteristics that could be contributing to the imbalance in induction mortality across institutions.

Interrogating Genomic Signatures of Pediatric Diffuse Large B Cell Lymphoma to Determine Potential Targeted Therapies

Non-Hodgkin Lymphoma

Background

Mature B cell lymphoma is the most common type of non-Hodgkin lymphoma in children and adolescents. Patients typically present having a fast growing, symptomatic mass with nodal enlargement in the neck or the abdomen. While outcome is typically favorable with standard chemotherapy, there are two main challenges that still arise. These include optimizing treatment to prevent relapse and minimizing long term side effects for survivors.

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