University of California San Francisco

University of California San Francisco

745 Parnassus Ave

San Francisco, CA 94143

United States

ABVD Without Radiation for Newly Diagnosed Pediatric Patients with Hodgkin Lymphoma: A Single Center Retrospective Analysis of 22 Consecutive Patients

Hodgkin Lymphoma

Background

Overcoming Glucocorticoid Resistance in Lymphoid Cancers

Acute Lymphoblastic Leukemia (ALL)

Investigating Racial Disparities in Pediatric Acute Leukemia

Leukemia

Background

Cancer takes the lives of more children than any other disease and leukemia is the most common type of childhood cancer. African-American children with leukemia die more often than children of other races with leukemia. The reasons for this difference between African-American and Caucasian children are unknown. While there are many possible causes of this difference, we have found in previous research that African-American children come to the hospital sicker than Caucasian children prior to the start of chemotherapy.

A CRISPRi Genetic Screen in Ewing sarcoma Identifies a Novel Dependence on Homologous Recombination DNA Repair

Ewing Sarcoma

Background

Sarcomas are tumors of the bone and soft tissues that comprise up to 20% of cancer diagnoses in children. Despite dismal outcomes for patients with recurrent or metastatic disease, treatment regimens consisting of intense non-specific chemotherapy combined with surgery or radiation remain largely unchanged for decades.

Genetic Predisposition to Atypical Teratoid/Rhabdoid Tumor Caused by Mutations in SWI/SNF Complex Genes

Atypical Teratoid/Rhabdoid Tumor (AT/RT)

Background

Optimizing Conformation Disrupting Aurora Kinase Inhibitors to Treat MYCN Amplified Neuroblastoma

Neuroblastoma

Background

Establishment and Validation of an IPS-based Neuroblastoma Model

Neuroblastoma

Background

Neuroblastoma is the most common extra-cranial solid childhood cancer, accounting for 15% of all cancer deaths in children. Targeted therapies hold promise to improve the outcome for children with high-risk neuroblastoma, however this issue remains challenging. Amplification of the MYCN oncogene occurs in half of high-risk patients.

Investigation of Causal Germline Mutations in High Hyperdiploid ALL

Acute Lymphoblastic Leukemia (ALL)

Background

High-dimensional Biochemical CyTOF Analysis of Pediatric T cell Leukemias

Acute Lymphoblastic Leukemia (ALL)

Background

Pediatric T cell Acute Lymphoblastic Leukemia (T-ALL) is an aggressive blood cancer and children are currently treated with chemotherapy but its non-specific and toxic aspect is problematic. More specific therapies are desired but T-ALL's differ from patient to patient and even within one patient there are cell subsets within the leukemia (called heterogeneity). It is therefore challenging to implement or analyze the effects of precision medicine that inhibit abnormally functioning proteins in T-ALL.

Targeting Secondary Mutations in Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic Leukemia (JMML)

Background

While most types of childhood leukemia are routinely cured with therapy, juvenile myelomonocytic leukemia (JMML), a type of blood cancer that affects young children remains exceedingly difficult to treat. Even when cured, the infants and toddlers affected by this disorder have difficulty tolerating the required treatment, which can be very intense. Equally frustrating, it is challenging to predict who will respond to the treatments we currently have versus those that will require experimental therapy in order to cure them of their cancer.

Alex's Lemonade Stand Foundation for Childhood Cancer