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Phase I/II Infrastructure Grants

Doctors have identified a critical lack of funding for support personnel who speed up the process of enrolling children with cancer in clinical trials. With grants from Alex's Lemonade Stand Foundation, hospitals across the country have created new positions, specifically focused on filling this critical need, bringing the latest treatments to more children.

Please note that the Phase I/II Infrastructure grant is not offered every year. Please view our Grants Calendar for upcoming grant opportunities.

This grant is no longer offered.

Doernbecher Children's Hospital Foundation

This grant will support the ongoing and future efforts of the Investigational Therapeutics Program at Doernbecher Children’s Hospital, OHSU. The time and effort required to maintain a high-quality Phase I program is considerable. Paramount to such a program is an infrastructure that ensures the safe and ethical conduct of these studies. Our Division of Pediatric Oncology is an active member of the Children’s Oncology Group (COG) Phase I Consortium and has enrolled over 30 patients onto investigational studies in the past three years.

Principal Investigator Name: 

Linda Stork, MD

Project Title: 

Pediatric Oncology Investigational Therapeutics.

Year Awarded: 

2007

Cancer Research Category: 

Category of Grant: 

Medical, Nurse Researcher, Quality of LIfe: 

Institution: 

Dana-Farber Cancer Institute

Project Goals
Create a program infrastructure to facilitate:
• Increased enrollment in early phase clinical trials for pediatric solid tumor patients
• Increased participation in biologic studies associated with early phase clinical trials
• Increased numbers of clinical trials and accelerate rapidity of their development, bringing novel agents and approaches from bench to bedside

Principal Investigator Name: 

Lisa Diller, MD

Project Title: 

Pediatric Oncology Clinical Research Infrastructure

Year Awarded: 

2007

Cancer Research Category: 

Category of Grant: 

Medical, Nurse Researcher, Quality of LIfe: 

Institution: 

The Children's Hospital Denver

I had the privilege of caring for a young cancer patient who first came to us when she was 3 ½ years old. Her doctors felt there was nothing more they could offer her for her T-cell leukemia as she had already received the most aggressive, state-of-the-art care and still her leukemia had come back. Her family became aware of a new drug that we had in a phase I trial, but the study had primarily enrolled adults. 

Principal Investigator Name: 

Lia Gore, MD

Project Title: 

Advancing Program Development and Support for the Pediatric Experimental Therapeutics Program at The Children's Hospital, Denver

Year Awarded: 

2007

Cancer Research Category: 

Category of Grant: 

Medical, Nurse Researcher, Quality of LIfe: 

Institution: 

University of California San Francisco

Project Goal
The goal of this project is for the Pediatric Oncology Neuroblastoma Research Program at UCSF Children’s Hospital to expand its research capabilities, continue to develop collaborative research projects, recruit additional staff members, and advance its clinical research capacity. These efforts are all undertaken to improve both the current and future treatment of patients with neuroblastoma, with a goal of ultimately removing the threat of this disease.

Our work at UCSF falls into several categories:

Principal Investigator Name: 

Katherine Matthay, MD

Project Title: 

131-I-MIBG and Targeted Therapy for Neuroblastoma: Infrastructure Proposal.

Year Awarded: 

2007

Cancer Research Category: 

Category of Grant: 

Medical, Nurse Researcher, Quality of LIfe: 

Institution: 

Children's Hospital Los Angeles

Update - 6/24:
Head Start III completed patient accrual, as anticipated, in December 2009, with a total of approximately 215 children enrolled from 38 participating centers in the USA, Canada, Australia, New Zealand and Switzerland.

Several presentations and papers based on the ALSF-supported clinical trial have appeared:

Principal Investigator Name: 

Jonathan Finlay, MD

Project Title: 

Saving Lives, Saving Neurons, the Head Start Consortium for Young Children with Malignant Central Nervous System Tumors

Year Awarded: 

2007

Cancer Research Category: 

Category of Grant: 

Medical, Nurse Researcher, Quality of LIfe: 

Institution: 

Children's Hospital Los Angeles

Neuroblastoma is the second most common solid cancer of children, and less than 50% of children survive who have the widespread (metastatic) form of the disease. The New Approaches to Neuroblastoma Therapy (NANT) consortium is a group of 13 university children’s cancer centers that are dedicated to finding new treatments that will cure more patients (see www.nant.org). The aim of our studies is to develop and test new therapeutic strategies that are developed in our laboratories and that may be effective against the most difficult neuroblastomas.

Principal Investigator Name: 

Robert Seeger

Project Title: 

New Approaches to Neuroblastoma Therapy

Year Awarded: 

2008

Cancer Research Category: 

Category of Grant: 

Medical, Nurse Researcher, Quality of LIfe: 

Institution: 

Children's Memorial Hospital

In the last fifty years survival for children with childhood cancer has risen dramatically. This remarkable increase in survival is directly related to patients' and families willingness and commitment to participate in well run clinical trials. For every child who is enrolled on a clinical trial there is an associated morale obligation on the part of the administering treatment/care facility to perform these trials in complete compliance with all study requirements and regulations.

Principal Investigator Name: 

Stewart Goldman

Project Title: 

Increasing the Availability and Quality of Early Phase Clinical Trials Through the Addition of a Specialized Pediatric Advanced Nurse Practitioner

Year Awarded: 

2008

Cancer Research Category: 

Category of Grant: 

Medical, Nurse Researcher, Quality of LIfe: 

Institution: 

University of Pittsburgh


In simple terms, what is your research project?   

Support for a new pediatric cancer drug therapy at Children's Hospital of Pittsburgh of UPMC.

What type of childhood cancer does your project focus on?

Principal Investigator Name: 

A. Kim Ritchey, MD

Project Title: 

Children's Hospital of Pittsburgh Phase 1-2 Infrastructure Support Grant

Year Awarded: 

2008

Cancer Research Category: 

Category of Grant: 

Medical, Nurse Researcher, Quality of LIfe: 

Institution: 

Columbia University

Trial development and scientific contribution by the investigators of The Children's Hospital of New York-Presbyterian at Columbia University, Pediatric Cancer Foundation Developmental Therapeutics Program (PCFDTP) led by Dr. Julia Glade Bender. See 2010 renewal description.

Principal Investigator Name: 

Julia Glade Bender, MD

Project Title: 

A New York Based Pediatric Oncology Developmental Therapeutics Program

Year Awarded: 

2008

Cancer Research Category: 

Category of Grant: 

Medical, Nurse Researcher, Quality of LIfe: 

Institution: 

Seattle Children's Hospital and Regional Medical Center

Despite advances in the treatment of cancer, the outcome for some of the most common childhood cancers remains extremely poor. Our pediatric oncology program at Children’s Hospital and Regional Medical Center is committed to investigate how to best administer currently available chemotherapy agents and how to develop new therapies for these childhood cancers. A successful Phase I/II clinical trial program is essential to our mission of advancing treatment of pediatric cancer and providing options to families and patients fighting cancer.

Principal Investigator Name: 

Julie Park, MD

Project Title: 

Advanced Therapeutics for Pediatric Cancer

Year Awarded: 

2008

Cancer Research Category: 

Category of Grant: 

Medical, Nurse Researcher, Quality of LIfe: 

Institution: 

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Featured Hero

Erin Ersoy

Erin is a pre-veterinary student and a cancer survivor. When she was 2 years old she underwent difficult treatment for neuroblastoma, and lives with many health complications. But she's a star, shining light on childhood cancer by sharing her own story.
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