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Phase I/II Infrastructure Grants

Doctors have identified a critical lack of funding for support personnel who speed up the process of enrolling children with cancer in clinical trials. With grants from Alex's Lemonade Stand Foundation, hospitals across the country have created new positions, specifically focused on filling this critical need, bringing the latest treatments to more children.

Please note that the Phase I/II Infrastructure grant is not offered every year. Please view our Grants Calendar for upcoming grant opportunities.

This grant is no longer offered.

The Children’s Hospital of Philadelphia

Disease-specific research teams at the Children's Hospital of Philadelphia (CHOP) have been successful in bench to bedside work, having identified key molecules involved in the genesis of neuroblastoma, and subsequently having studied agents that target these molecules in preclinical and clinical settings. From a programmatic point of view, it is logical to build upon this success and apply the bench to bedside paradigm beyond the disease-specific setting.

Principal Investigator Name: 

Rochelle Bagatell

Project Title: 

Biology-based clinical trials for children with cancer.

Year Awarded: 

2009

Cancer Research Category: 

Category of Grant: 

Medical, Nurse Researcher, Quality of LIfe: 

Institution: 

Children’s Hospital of Denver

“We have been able to offer promising treatments to the children and families who need them most. There are kids who are alive today who would not be without the treatment that we were able to offer.” - Lia Gore, MD

Background

Principal Investigator Name: 

Lia Gore, MD

Project Title: 

Expanding access to new agents for children with refractory cancers: the experimental therapeutics program at Children's Hospital of Colorado.

Year Awarded: 

2009

Cancer Research Category: 

Category of Grant: 

Medical, Nurse Researcher, Quality of LIfe: 

Institution: 

Aflac Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta

The Aflac Cancer Center and Blood Disorders Service at Children’s Healthcare of Atlanta (CHOA) is one of the largest pediatric oncology programs in the United States and an important contributor to accrual on cooperative group clinical trials both for newly diagnosed and relapsed patients. In 2005, a total of 320 newly diagnosed patients were seen and a total of 73 stem cell transplants were performed. In addition, 92 relapsed patients were seen, unfortunately some of whom had recurred on more than one occasion.

Principal Investigator Name: 

Howard Katzenstein, MD

Project Title: 

CHOA Experimental Therapy Pediatric Oncology Research.

Year Awarded: 

2006

Cancer Research Category: 

Category of Grant: 

Medical, Nurse Researcher, Quality of LIfe: 

Institution: 

The Children's Hospital Denver

The majority of children diagnosed with cancer in the US are cured with modern, intensive treatment strategies. However despite this good outcome for most patients, a proportion will do very poorly, and have little hope for a cure. As such, novel approaches to therapy and new drugs are clearly needed for these patients. There has been an explosion in the research and development of treatments for cancer in recent years, but unfortunately, moving these agents to pediatric patients has been slow.

Principal Investigator Name: 

Lia Gore, MD

Project Title: 

Expanding Access to New Agents for Cancer Treatment.

Year Awarded: 

2006

Cancer Research Category: 

Category of Grant: 

Medical, Nurse Researcher, Quality of LIfe: 

Institution: 

Seattle Children's Hospital & Regional Medical Center

Project Goals
Our overall goals were to optimize the effectiveness of current chemotherapy agents and enhance development of novel chemotherapeutic agents for treatment of aggressive childhood cancers. Specifically we proposed to:  

Principal Investigator Name: 

Julie Park, MD

Project Title: 

Use sophisticated approaches to optimize the effectiveness of current chemotherapy agents, and to develop novel chemotherapy agents

Year Awarded: 

2006

Cancer Research Category: 

Category of Grant: 

Medical, Nurse Researcher, Quality of LIfe: 

Institution: 

Baylor College of Medicine

Project Goal

The funding provided initial support for developing a neuroblastoma referral center.

Results

We now get more referrals for children with neuroblastoma than any other program in the Southwest.

For our patients with neuroblastoma, we have been able to support the development of multiple clinical trials, including both local investigator–initiated trials and collaborative multi-institutional trials.

Principal Investigator Name: 

Heidi Russell, MD

Project Title: 

Building a Texas-based center for neuroblastoma clinical research.

Year Awarded: 

2006

Cancer Research Category: 

Category of Grant: 

Medical, Nurse Researcher, Quality of LIfe: 

Institution: 

Vanderbilt University Medical Center

Primary Investigator relocated to the Hospital for Sick Children, Toronto, Canada. See description for Dr. Whitlock's 2011 Phase I/II Infrastructure Grant.

Principal Investigator Name: 

James Whitlock, MD

Project Title: 

Pediatric Oncology Translational Research Program.

Year Awarded: 

2006

Cancer Research Category: 

Category of Grant: 

Medical, Nurse Researcher, Quality of LIfe: 

Institution: 

Children's Hospital Los Angeles

Neuroblastoma is the second most common solid cancer of children, and less than 50% of children survive who have the widespread (metastatic) form of the disease. The New Approaches to Neuroblastoma Therapy (NANT) consortium is a group of 13 university children’s cancer centers that are dedicated to finding cures for this disease. 

Principal Investigator Name: 

Robert Seeger, MD

Project Title: 

New Approaches to Neuroblastoma Therapy (NANT) Consortium

Year Awarded: 

2006

Cancer Research Category: 

Category of Grant: 

Medical, Nurse Researcher, Quality of LIfe: 

Institution: 

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Featured Hero

Erin Ersoy

Erin is a pre-veterinary student and a cancer survivor. When she was 2 years old she underwent difficult treatment for neuroblastoma, and lives with many health complications. But she's a star, shining light on childhood cancer by sharing her own story.
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