ALSF Childhood Cancer Research Grants
With your support, we have been able to fund outstanding research, leading toward cures and improved quality of life for children with cancer. Browse through more than 1,500 funded projects below.
Use the search tool to refine your results. You can also click on a heading to sort by project title, institution name, or year the grant was awarded. Click on the project title to read more information.
You can learn about ALSF's grant review process here.
ALSF Funded Research Projects
| Project Title | Institution / Principal Investigator(s) | Grant Type | Year | State |
|---|---|---|---|---|
| Circadian Rhythms, Fatigue and Bright Light Therapy in Adolescent Cancer Survivors | University of Maryland, College Park / Valerie E. Rogers, PhD | Nurse Researcher Grants | 2015 | Maryland |
| Adoptive Immunotherapy of Tr1 Cells to Improve Outcome of Allo-HSCT Treatment for Pediatric AML | Stanford University / Maria-Grazia Roncarolo, MD & Rosa Bachetta, MD | Reach Grants | 2015 | California |
| Targeting Novel Pediatric-Specific FLT3 Mutations | Fred Hutchinson Cancer Research Center / Soheil Meshinchi, MD,PhD | Reach Grants | 2015 | Washington |
| Therapeutic Reactivation of p53 to Overcome Apoptotic Resistance in Pediatric Leukemia | Dana-Farber Cancer Institute / Loren Walensky, MD, PhD & Kimberly Stegmaier, MD | Reach Grants | 2015 | Massachusetts |
| Targeting PI3Kdelta in Childhood Acute Lymphoblastic Leukemia | Children’s Hospital Los Angeles / Yong-mi Kim, MD & Nora Heisterkamp, PhD | Reach Grants | 2015 | California |
| Screen to Intervene: A Family-Centered Approach to Identifying and Communicating Family Psychosocial Risk and Developing Evidence Based Clinical Pathways in Hematopoietic Stem Cell Transplantation | Alfred I duPont Hospital for Children / Anne Kazak, PhD | Psychosocial Grants | 2015 | Delaware |
| Factors Affecting Parental Satisfaction, Anxiety and Comprehension of the Informed Consent in Pediatric Oncology Clinical Trials | University of California, San Diego / Paula Aristizabal, MD | Psychosocial Grants | 2015 | California |
| Inside-Out Immunotherapy: Combating Neuroblastoma via Nanoparticle-Directed Reprogramming of the Tumor Microenvironment | Vanderbilt University Medical Center / John Wilson, PhD | 'A' Award Grants | 2015 | Tennessee |
| Targeting the LIN28 Pathway in ATRT | The Johns Hopkins University School of Medicine / Eric Raabe, MD, PhD | 'A' Award Grants | 2015 | Maryland |
| Genetically Modified, Cord Blood Derived Natural Killer Cell Therapy for High Grade Pediatric Brain Tumors | Children’s Research Institute / Conrad Russell Cruz, MD, PhD | 'A' Award Grants | 2015 | District of Columbia |
| Next-Generation Personalized Neuroblastoma Therapy (Nepenthe) | Children’s Hospital of Philadelphia / Yael Mosse, MD & John Maris, MD | Bio-Therapeutic Impact Award | 2015 | Pennsylvania |
| Prospective Symptom Assessment in Children with Advanced Cancer | University of Wisconsin - Madison / Kathleen Montgomery, PhD & Jennifer Madden, RN/MSN | Nurse Researcher Grants | 2015 | Wisconsin |
| Cure Osteosarcoma Lung Metastasis by Disrupting Tumor VCAM-1 Signaling with Macrophages | Case Western Reserve University / Alex Huang, MD, PhD | Innovation Grants | 2015 | Ohio |
| DNA Sequencing Using Malaria Slides | Indiana University / Terry Vik, MD | Epidemiology Grants | 2015 | Indiana |
| Phase I and II Clinical Research Program Infrastructure Award | University of Minnesota / Brenda Weigel, MD & Emily Greengard MD | Phase I/II Infrastructure Grants | 2015 | Minnesota |
| Expanding Innovative Pediatric Cancer Clinical Trial Access at Stanford | Stanford University / Maria-Grazia Roncarolo, M.D. & Sherri Spunt, M.D. | Phase I/II Infrastructure Grants | 2015 | California |
| Building Capacity for the Clinical Trials Office at Children's Hospital of Wisconsin - Strengthening Phase I & II Trials Infrastructure | Children’s Hospital of Wisconsin - Milwaukee / Michael J. Burke, MD | Phase I/II Infrastructure Grants | 2015 | Wisconsin |
| Space-Time Analysis of the California Birth Cohort: 30 Years of Childhood Cancer | University of California Berkeley / Steve Selvin, PhD | Epidemiology Grants | 2015 | California |
| In Vivo Analysis of Early Neuroblastoma Development using Transgenic Quail | Stowers Institute for Medical Research / Paul Kulesa, PhD | Innovation Grants | 2015 | Missouri |
| Histone H3.3 Targeted Therapy for Pediatric High-grade Gliomas | University of California, Davis Medical Center / Paul Knoepfler, PhD | Innovation Grants | 2015 | California |
| Regulation of Tumor Debris Mediated Inflammation as a Therapeutic Modality in Medulloblastoma | Dana-Farber Cancer Institute / Mark Kieran, MD, PhD & Dipak Panigrahy, MD | Innovation Grants | 2015 | Massachusetts |
| Identifying Mechanisms of Glucocorticoid Resistance in Pediatric Acute Lymphoblastic | University of Massachusetts Medical School / Michelle Kelliher, PhD | Innovation Grants | 2015 | Massachusetts |
| Enhanced Drug Repurposing Screen in DSRCT Enabled by New In Vitro and In Vivo Models Based on CRISPR/Cas9 Genome Engineering | Memorial Sloan-Kettering Cancer Center / Marc Ladanyi, MD & Maria Jasin, PhD | Innovation Grants | 2015 | New York |
| High-dimensional Biochemical CyTOF Analysis of Pediatric T cell Leukemias | University of California San Francisco / Jeroen Roose, PhD | Innovation Grants | 2015 | California |
| Developing a Novel Tumor Model to Screen for New Therapies for Spinal Ependymoma | The Johns Hopkins University School of Medicine / Linda Resar, MD & Richard Schlegel, MD, PhD | Innovation Grants | 2015 | Maryland |
| Integrative Genomic and Immunogenomic Analysis of Neuroblastoma | University of California at Santa Cruz / David Haussler, PhD | Innovation Grants | 2015 | California |
| Identifying Epigenetic Mechanisms Impacting Neuroblastoma Genome Stability and Drug Response | Massachusetts General Hospital / Johnathan Whetstine, PhD | Innovation Grants | 2015 | Massachusetts |
| Optimizing Bispecific Antibody Therapy for Acute Leukemias | Fred Hutchinson Cancer Research Center / Roland Walter, MD, PhD & James Olson, MD, PhD | Innovation Grants | 2015 | Washington |
| Functional Analysis and Therapeutic Targeting of STAG2 Mutations in Ewing sarcoma | Georgetown University / Todd Waldman, MD, PhD | Innovation Grants | 2015 | District of Columbia |
| Identifying how Pre-existing Anti-Therapeutic Antibodies (PATA) are Associated with Better Outcome in a Clinical Trial of ADCC-inducing Anti-GD2 mAb | University of Wisconsin - Madison / Paul Sondel, MD, PhD | Innovation Grants | 2015 | Wisconsin |
| Antibody Targeted Natural Killer Cell-Derived Extracellular Vesicles for the Treatment of Childhood Acute Lymphoblastic Leukemia and Neuroblastoma | Children’s Hospital Los Angeles / Robert Seeger, MD & Alan Wayne, MD | Innovation Grants | 2015 | California |
| Preclinical Development of Atr Inhibitor VE-822, Delivered Systemically in Nanoparticles, for Medulloblastoma Therapy | University of North Carolina / Timothy Gershon, MD, PhD | Innovation Grants | 2015 | North Carolina |
| Pharmacogenomics and Drug Screening Lead to a Novel Targeted Therapy with Potent and Specific Activity Against Mouse Models of MYCN-amplified Neuroblastoma | Virginia Commonwealth University / Anthony Faber, MD & Yael Mosse, MD (CHOP) | Innovation Grants | 2015 | Virginia |
| Single Cell Analysis of Leukemia Initiation | Stanford University / Michael Cleary, MD | Innovation Grants | 2015 | California |
| Transcriptional Effectors of Activated RAS Signaling in Juvenile Myelomonocytic Leukemia | Boston Children’s Hospital / Alan Cantor, MD, PhD | Innovation Grants | 2015 | Massachusetts |
| Synergistic Differentiation Therapy in Neuroblastoma | Duke University / Gerard Blobe, M.D./Ph.D | Innovation Grants | 2015 | North Carolina |
| Enhancing Effectiveness of Immune Checkpoint Therapy in Neuroblastoma | Children’s Hospital Los Angeles / Shahab Asgharzadeh, MD | Innovation Grants | 2015 | California |
| Small Molecule Inhibitors of ERG for Pediatric Leukemia and Sarcoma | University of Virginia, School of Medicine / John Bushweller, PhD | Innovation Grants | 2015 | Virginia |
| Characterizing Resistance Mechanisms to BET-Bromodomain Inhibition in MYC-amplified | Broad Institute / Rameen Beroukhim, MD,PhD | Innovation Grants | 2015 | Massachusetts |
| Novel Nanoscale Phosphoproteomic Discovery of Therapeutic Targets in AML Stem Cells | Dana-Farber Cancer Institute / Leo Wang, MD, PhD | Young Investigator Grants | 2015 | Massachusetts |
| The Role of DEF and SSU Processome in Neuroblastoma Pathogenesis | Dana-Farber Cancer Institute / Ting Tao, PhD | Young Investigator Grants | 2015 | Massachusetts |
| CAMKV as a Target for Immunotherapy in MYCN-Amplified Neuroblastoma | Children’s Hospital of Philadelphia / Robyn Sussman, PhD | Young Investigator Grants | 2015 | Pennsylvania |
| Targeting Secondary Mutations in Juvenile Myelomonocytic Leukemia | University of California San Francisco / Elliot Stieglitz, MD | Young Investigator Grants | 2015 | California |
| Enhancing the Viability, Function, and Safety, of Genetically-Enhanced NK Cells Within the Solid Tumor Microenvironment With IL-15 and a Suicide Gene | Baylor College of Medicine / Robin Parihar, MD, PhD | Young Investigator Grants | 2015 | Texas |
| Zebrafish Modeling of PAX3-FOXO1 Driven Rhabdomyosarcoma | University of Texas Southwestern Medical Center / Genevieve Kendall, PhD | Young Investigator Grants | 2015 | Texas |
| Elucidating Mechanisms Driving Renal Medullary Carcinomas to Deliver a Rational Approach to Cancer Directed Therapy | Dana-Farber Cancer Institute / Andrew Hong, MD | Young Investigator Grants | 2015 | Massachusetts |
| Functional Dissection of Oncogenic Enhancers in T-ALL | Columbia University / Daniel Herranz, PhD | Young Investigator Grants | 2015 | New York |
| Critical Contributions of CRM1 to Leukemogenesis | University of Vermont / Jessica Linda Heath, MD | Young Investigator Grants | 2015 | Vermont |
| A Translational Approach to Identify Drugs with Specific Activity Against EZH2 Mutant High Risk T-ALLs and ETP ALLs that Overexpress the JDP2 bZIP Transcription Factor | Dana-Farber Cancer Institute / Shuning He, PhD | Young Investigator Grants | 2015 | Massachusetts |
| The Effect of Locus of Care Upon Adolescent and Young Adults Cancer Outcomes: An IMPACT Cohort Study | Hospital for Sick Children / Sumit Gupta, MD, PhD | Young Investigator Grants | 2015 | Ontario |
| Novel Role of Hematopoietic Stem Cells in Immunologic Rejection of Malignant Pediatric Brain Tumors | University of Florida / Catherine Flores, PhD | Young Investigator Grants | 2015 | Florida |
| Genetic Dissection of Cancer Drug Resistance and Toxicity Using Haploid Human Cells | Stanford University / Ramin Dubey, PhD | Young Investigator Grants | 2015 | California |
| The YB1 Way of Surviving Radiation, Pediatric Brain Tumor Resistance and Recurrence | Emory University / Abhinav Dey, PhD | Young Investigator Grants | 2015 | Georgia |
| Engager T Cells: A Novel Immunotherapeutic for AML | University of Michigan / Challice Bonifant, MD, PhD | Young Investigator Grants | 2015 | Michigan |
| Regulation of Hematopoietic Stem Cell Engraftment by the Endothelial Cell Niche | Boston Children’s Hospital / Bradley Blaser, MD, PhD | Young Investigator Grants | 2015 | Massachusetts |
| The Role of PARP3 in the Formation of Chromosomal Translocations | Dana-Farber Cancer Institute / Tovah Day, PhD | Young Investigator Grants | 2015 | Massachusetts |
| The Cebpa Downstream Enhancer as a Key Target of Transformation to Acute Myeloid Leukemia | The Johns Hopkins University School of Medicine / Stacy Cooper, MD | Young Investigator Grants | 2015 | Maryland |
| Elucidating the Mechanism of ERK Mediated Pathogenesis of LCH | Baylor College of Medicine / Rikhia Chakraborty, PhD | Young Investigator Grants | 2015 | Texas |
| Chemical Genetics and CRISPRi/a Screen for Novel Therapeutic Targets in a Humanized Model for MYCN Associated High-Risk Pediatric Neuroblastoma | University of California San Francisco / Zhenyi An, PhD | Young Investigator Grants | 2015 | California |
| Understanding the Role of Translational Control in Humanized Mouse Models for Medulloblastoma | University of California San Francisco / Ozlem Aksoy, PhD | Young Investigator Grants | 2015 | California |
| Molecular Annotation for Treatment of Childhood Cancers Trial: Neuroblastoma (MATCH-NB) | Children’s Hospital of Philadelphia / Yael Mosse, M.D. | Bio-Therapeutic Impact Award | 2015 | Pennsylvania |