ALSF Childhood Cancer Research Grants
With your support, we have been able to fund outstanding research, leading toward cures and improved quality of life for children with cancer. Browse through more than 1,500 funded projects below.
Use the search tool to refine your results. You can also click on a heading to sort by project title, institution name, or year the grant was awarded. Click on the project title to read more information.
You can learn about ALSF's grant review process here.
ALSF Funded Research Projects
| Project Title | Institution / Principal Investigator(s) | Grant Type | Year | State |
|---|---|---|---|---|
| Cell Line and Xenograft Repository | Texas Tech University Health Sciences Center / Patrick Reynolds, MD/PhD | Catalyst Grants | 2014 | Texas |
| Pediatric Oncology Nurses' Experiences with Prognosis-Related Communication | Marquette University / Amy Newman, RN, MSN | Nurse Researcher Grants | 2014 | Wisconsin |
| Symptom Patterns during Pediatric Hematopoietic Stem Cell Transplant Recovery | Duke University Medical Center / Cheryl Rodgers, RN, PhD | Nurse Researcher Grants | 2014 | North Carolina |
| KAM: Kids are Moving; An Exercise Program for Children with Cancer | University of Minnesota / Mary Catherine (Casey) Hooke, PhD | Nurse Researcher Grants | 2014 | Minnesota |
| Development of a Screening Module to Assess Sibling-Related Psychosocial Risk in Families of Children with Cancer | Boston University / Kristin Long, PhD | Psychosocial Grants | 2014 | Massachusetts |
| Neurocognitive Assessments within COG: An Intensive, Integrated Model for Successfully Evaluating Children with High-Risk ALL | Children’s Research Institute / Kristina Hardy, PhD | Psychosocial Grants | 2014 | District of Columbia |
| Genetic Susceptibility to Pediatric Osteosarcoma and Interaction with Measures of Childhood Growth | Duke University / Kyle Walsh, Ph.D. | 'A' Award Grants | 2014 | North Carolina |
| Investigating the Role of Genetic and Epigenetic Variation in Risk of Childhood Acute Lymphoblastic Leukemia in Down Syndrome | University of California San Francisco / Adam de Smith, Ph.D. | 'A' Award Grants | 2014 | California |
| The Role of MST1 in Non-canonical Hippo Signaling in Rhabdomyosarcoma | Duke University / Lisa Crose, Ph.D. | 'A' Award Grants | 2014 | North Carolina |
| Immunotherapy of Neuroblastoma with CAR.GD2 NKT Cells | Baylor College of Medicine / Leonid S. Metelitsa, M.D., Ph.D. | Bio-Therapeutic Impact Award | 2014 | Texas |
| Phase I Trial of Indoximod in Combination with Temozolomide-based Therapy for Children with Progressive Primary Brain Tumors | Georgia Health Sciences University Research Institute, Inc. / Theodore Johnson, M.D., Ph.D. | Bio-Therapeutic Impact Award | 2014 | Georgia |
| HA-1 TCR T-cell Immunotherapy for Acute Leukemia | Fred Hutchinson Cancer Research Center / Marie Bleakley, M.D., Ph.D. | Bio-Therapeutic Impact Award | 2014 | Washington |
| DNA Methylation Inhibitor Therapy for Testicular Germ Cell Tumors | University of Illinois, Urbana-Champaign / Michael Spinella, Ph.D. | Reach Grants | 2014 | Illinois |
| Targeted Inhibition of the DNA Damage Response Pathway: A Novel Intervention in the Treatment of Pediatric Leukemias | National Cancer Institute / Andre Nussenzweig, Ph.D. | Reach Grants | 2014 | Maryland |
| A Novel Target for Neuroblastoma Treatment | Beckman Research Institute of City of Hope / Linda Malkas, Ph.D. | Reach Grants | 2014 | California |
| Identifying Novel Therapeutic Combinations with 131I-MIBG to Treat Relapsed and Refractory Neuroblastoma | The Regents of the University of California San Francisco / William Clay Gustafson, M.D., Ph.D. | Reach Grants | 2014 | California |
| Identification of Rhabdomyosarcoma Therapies Using an Efficient Mouse and Drosophila Repurposing Screen | Memorial Sloan-Kettering Cancer Center / Mary Baylies, Ph.D. | Reach Grants | 2014 | New York |
| Targeting eEF2 Kinase in Neuroblastoma | University of California San Francisco / William Weiss, M.D., Ph.D. | Innovation Grants | 2014 | California |
| Modeling Juvenile Myelomonocytic Leukemia with Patient-Derived Induced Pluripotent Stem Cells | Children’s Hospital of Philadelphia / Mitchell Weiss, M.D., Ph.D. | Innovation Grants | 2014 | Pennsylvania |
| Targeting the Accomplices of MYC in MYC-driven Medulloblastoma | Sanford-Burnham Medical Research Institute / Robert Wechsler-Reya, Ph.D. | Innovation Grants | 2014 | California |
| The Tumor Suppressive Role of LNK (SH2B3) in Acute Lymphoblastic Leukemia | Children’s Hospital of Philadelphia / Wei Tong, PhD | Innovation Grants | 2014 | Pennsylvania |
| Therapies for SHH-subtype Medulloblastoma | Dana-Farber Cancer Institute / Rosalind Segal, M.D., Ph.D. | Innovation Grants | 2014 | Massachusetts |
| Targeting Tumor Suppressor MicroRNAs in Pediatric Acute Lymphoblastic Leukemia | The Johns Hopkins University School of Medicine / Linda Resar, M.D. | Innovation Grants | 2014 | Maryland |
| Trib2 in the Pathogenesis of T-ALL | University of Pennsylvania / Warren Pear, M.D., Ph.D., | Innovation Grants | 2014 | Pennsylvania |
| Correction of Hematopoietic Defects in Down Syndrome by Chromosome 21 Silencing | University of Massachusetts Medical School / Peter Newburger, M.D. | Innovation Grants | 2014 | Massachusetts |
| Role of LMO1 in Neuroblastoma Initiation and Maintenance: Analysis in the Zebrafish model of Childhood Neuroblastoma | Dana-Farber Cancer Institute / Thomas Look, M.D. | Innovation Grants | 2014 | Massachusetts |
| Identifying Drug Resistant Mutations in Ph-like Acute Lymphoblastic Leukemia | University of California San Francisco / Mignon Loh, M.D. | Innovation Grants | 2014 | California |
| Mechanisms of LGR5 Regulation and Function in Ewing sarcoma Metastasis | University of Michigan / Elizabeth Lawlor, M.D., Ph.D. | Innovation Grants | 2014 | Michigan |
| Modeling the Multi-hit Pathogenesis of t(12;21) Associated Pediatric ALL by CRISPR/Cas-mediated Genome Engineering | Massachusetts General Hospital / Hanno Hock, M.D., Ph.D. | Innovation Grants | 2014 | Massachusetts |
| Developing Personalized (precision) Medicine Strategies to Optimize Pediatric Brain Tumor Management | Washington University / David Gutmann, M.D., Ph.D. | Innovation Grants | 2014 | Missouri |
| Two-pronged Cell Therapy: Engineering T Cells to Redirect Bystander T- and NK-Cells to Pediatric Cancer | Baylor College of Medicine / Stephen Gottschalk, M.D. | Innovation Grants | 2014 | Texas |
| Development of AAV Vectors for Efficient Targeting and Elimination of Osteosarcoma Tumor-Initiating Cells | University of Florida / Steven Ghivizzani, Ph.D. | Innovation Grants | 2014 | Florida |
| Targeting MYC/MYCN-driven Transcriptional Amplification in Pediatric Cancer | Dana-Farber Cancer Institute / Rani George, M.D., Ph.D. | Innovation Grants | 2014 | Massachusetts |
| Converting the Glioblastoma Multiforme Tumor-Associated Macrophage Phenotype | The Johns Hopkins University School of Medicine / Alan D. Friedman, M.D. | Innovation Grants | 2014 | Maryland |
| Targeting the Six1/Eya Transcriptional Complex to Inhibit Pediatric Sarcomas | University of Colorado Denver / Heide Ford, Ph.D. | Innovation Grants | 2014 | Colorado |
| Mechanisms and Targeted Inhibition of NT5C2 Mutations in Relapsed ALL | Columbia University / Adolfo A. Ferrando, M.D., Ph.D. | Innovation Grants | 2014 | New York |
| Exploiting Epigenetic Dependencies of Notch1 for Clinical Benefit | University of Colorado Denver / Patricia Ernst, Ph.D. | Innovation Grants | 2014 | Colorado |
| Development of Targeted Leukemia Inhibitors Using Nanoparticle Delivery | University of Massachusetts Medical School / Lucio Castilla, Ph.D. | Innovation Grants | 2014 | Massachusetts |
| Trk-Targeted Therapy of Human Neuroblastomas | Children’s Hospital of Philadelphia / Garrett Brodeur, M.D. | Bridge Grants | 2014 | Pennsylvania |
| STAT3 Signaling Profiles Predict Response to Chemotherapy in Pediatric AML | Baylor College of Medicine / Michele Redell, M.D./Ph.D. | Springboard Grants | 2014 | Texas |
| Exosomes as Biomarkers to Monitor Disease Progression and Response to Therapy in Ewing sarcoma | Children’s Mercy / Glenson Samuel, MD | Young Investigator Grants | 2014 | Missouri |
| Hospital Volume and Induction Mortality in Children, Adolescents, and Young Adults with Acute Leukemia | Children’s Hospital of Philadelphia / Jennifer Wilkes, MD | Young Investigator Grants | 2014 | Pennsylvania |
| Optimizing Engager T-cells for CD19+ Malignancies | Baylor College of Medicine / Mireya Paulina Velasquez, MD | Young Investigator Grants | 2014 | Texas |
| Identification of Resistance Mechanisms and Novel Therapeutic Strategies in Tyrosine Kinase Inhibitor Resistant FLT3/ITD Acute Myeloid Leukemia | Fred Hutchinson Cancer Research Center / Katherine Tarlock, MD | Young Investigator Grants | 2014 | Washington |
| Targeting Aberrant Hh Signaling with BET Bromodomain Inhibition as a Novel Therapeutic Strategy Against MB and DIPG | Lucile Packard Children’s Hospital at Stanford University School of Medicine / Yujie Tang, PhD | Young Investigator Grants | 2014 | California |
| Understanding and Preventing Healthy Tissue Damage in Pediatric Cancer Patients | Dana-Farber Cancer Institute / Kristopher Sarosiek, PhD | Young Investigator Grants | 2014 | Massachusetts |
| Deciphering the Mechanisms of Medulloblastoma Treatment Resistance using Integrative Genomics | Hospital for Sick Children / Vijay Ramaswamy, MD | Young Investigator Grants | 2014 | Ontario |
| Targeted Therapy for Core Binding Factor Leukemia | University of Massachusetts Medical School / John Pulikkan, PhD | Young Investigator Grants | 2014 | Massachusetts |
| Translating BET Bromodomain Inhibitors for Acute Myeloid Leukemia Therapy | Dana-Farber Cancer Institute / Yana Pikman, MD | Young Investigator Grants | 2014 | Massachusetts |
| Investigation of Oncogenic Long Non-coding RNAs in Ewing sarcoma | Lucile Packard Children’s Hospital at Stanford University School of Medicine / Siu Ping Ngok, PhD | Young Investigator Grants | 2014 | California |
| Autophagy and mTOR Inhibition in Pediatric Gliomas with BRAF Mutations | University of Colorado Denver / Jean Mulcahy Levy, MD | Young Investigator Grants | 2014 | Colorado |
| Ca2+ Release Activated Ca2+ (CRAC) Channels in Control of Leukemic Cell Metabolism and Leukemia Stem Cell Maintenance in T-ALL | New York University School of Medicine / Mate Maus, PhD | Young Investigator Grants | 2014 | New York |
| SETD2 Mutations in Prognosis and Chemotherapy Resistance in Relapsed Acute Lymphoblastic Leukemia | Dana-Farber Cancer Institute / Brenton Mar, MD, PhD | Young Investigator Grants | 2014 | Massachusetts |
| Mechanisms of CNOT3 Tumor Suppression in T-ALL and Identification of New Drugs That Specifically Kill CNOT3-Deficient T-ALL Cells | Dana-Farber Cancer Institute / Zhaodong Li, PhD | Young Investigator Grants | 2014 | Massachusetts |
| Development of Targeted DNA-damaging Therapy for ATRX-deficient Pediatric Glioblastoma | University of Michigan / Carl Koschmann, MD | Young Investigator Grants | 2014 | Michigan |
| Molecular Mechanism and Development of Therapeutic Strategies Targeting MYCN-induced Calcium Signaling in Advanced Neuroblastoma | University of Hawaii at Hilo / Ingo Koomoa-Lange, PhD | Young Investigator Grants | 2014 | Hawaii |
| A Developmental Model to Characterize the Epigenetic Origins of the Retinoblastoma Tumor Initiating Cell | The Johns Hopkins University School of Medicine / Jeffrey Huo, MD, PhD | Young Investigator Grants | 2014 | Maryland |
| Immunotherapy Of Neuroblastoma With Natural Killer T Cells Engineered To Target O-acetyl-GD2 | Baylor College of Medicine / Andras Heczey, MD | Young Investigator Grants | 2014 | Texas |
| Niche for in Vitro Generation of Hematopoietic Stem Cells from Pluripotent Stem Cells | Fred Hutchinson Cancer Research Center / Brandon Hadland, MD, PhD | Young Investigator Grants | 2014 | Washington |
| APOBEC3 in Pediatric Leukemia: a Biomarker for Sensitivity to PARP Inhibition? | Children’s Hospital of Philadelphia / Abby Green, MD | Young Investigator Grants | 2014 | Pennsylvania |
| Targeting the Thymic Stromal Lymphopoeitin Receptor Signaling Axis to Reduce Relapse of High Risk Pediatric Acute Lymphoblastic Leukemia | National Cancer Institute / Christopher Chien, PhD | Young Investigator Grants | 2014 | Maryland |
| Targeting the Epigenome of Diffuse Intrinsic Pontine Glioma | The Johns Hopkins University School of Medicine / Sama Ahsan, MD | Young Investigator Grants | 2014 | Maryland |
| Serious Morbidity and Financial Outcomes Among Pediatric Cancer Survivors | Fred Hutchinson Cancer Research Center / Beth Mueller, PhD | Epidemiology Grants | 2014 | Washington |
| Perinatal Hormonal Biomarkers and Risk of Testicular Germ Cell Tumors | University of California Berkeley / Catherine Metayer, MD, PhD | Epidemiology Grants | 2014 | California |
| Exploring the Intersection between Childhood Cancer and Birth Defects to Identify Novel Cancer Predisposition Syndromes | Baylor College of Medicine / Philip Lupo, PhD | Epidemiology Grants | 2014 | Texas |
| Genomic Discovery of Wilms Tumor | Samuel Lunenfeld Research Institute of Mount Sinai Hospital / Rayjean Hung, PhD | Epidemiology Grants | 2014 | Ontario |