ALSF Childhood Cancer Research Grants
With your support, we have been able to fund outstanding research, leading toward cures and improved quality of life for children with cancer. Browse through more than 1,500 funded projects below.
Use the search tool to refine your results. You can also click on a heading to sort by project title, institution name, or year the grant was awarded. Click on the project title to read more information.
You can learn about ALSF's grant review process here.
ALSF Funded Research Projects
Project Title | Institution / Principal Investigator(s) | Grant Type | Year | State |
---|---|---|---|---|
GD2-directed CAR T cell therapy for H3K27M+ spinal cord diffuse midline glioma | Board of Trustees of the Leland Stanford Junior University / Michelle Monje | Catalyst Grants | 2021 | California |
The Role of LIN28B-let-7-PBK Axis on the Growth and Metastasis of Group 3 Medulloblastoma | Emory University / Shubin Shahab, MD/PhD | Young Investigator Grants | 2021 | Georgia |
Exploiting the Potential of Bromodomain Inhibitors in Ewing Sarcoma | Seattle Children’s Hospital / Shireen Ganapathi, MD | Young Investigator Grants | 2021 | Washington |
Dissecting the Contribution and Inheritance of Germline DNA Damage Repair Gene Mutations in Neuroblastoma | Dana-Farber Cancer Institute / Riaz Gillani, MD | Young Investigator Grants | 2021 | Massachusetts |
Dissecting Functional uORFs as a Source of Cancer Genes in High-Risk Medulloblastoma | Dana-Farber Cancer Institute / John Prensner, MD/PhD | Young Investigator Grants | 2021 | Massachusetts |
Social Determinants of Health, Hospital-level Resources, and Risk of Septic Shock in Pediatric Leukemia | Children’s Hospital of Philadelphia / Jenny Ruiz, MD | Young Investigator Grants | 2021 | Pennsylvania |
Redefining Osteosarcoma Metastases as Chronic Non-healing Lung Wounds: Implications for Developing Novel Therapies | Research Institute at Nationwide Children's Hospital / James Reinecke, MD/PhD | Young Investigator Grants | 2021 | Ohio |
Activating Metabolic Pathways to Increase the Persistence of Leukemia Targeting T Cells | Children’s Hospital of Pittsburgh / Erica Braverman, MD | Young Investigator Grants | 2021 | Pennsylvania |
STING Pathway Activation: The Missing Link between Genomic Instability and Antitumor Immunity in Osteosarcoma | University of California San Francisco / Elizabeth Young, MD | Young Investigator Grants | 2021 | California |
Hematopoietic Stem And Progenitor Cells Sustain Inflammation And Promote Relapse In The AML Niche | Children’s Hospital of Philadelphia / Ding-Wen (Roger) Chen, PhD | Young Investigator Grants | 2021 | Pennsylvania |
Investigating Epigenetic Mechanisms of Response to Allogenic CAR T Cell Therapy | St. Jude Children’s Research Hospital / Caitlin Zebley, MD/PhD | Young Investigator Grants | 2021 | Tennessee |
Neural Crest Gene Regulatory Networks Underlying Normal Meningeal Development and Onset of Meningioma | California Institute of Technology / Ayyappa Raja Desingu Rajan, PhD | Young Investigator Grants | 2021 | California |
Function and Dependency of NFkB Activity in ZFTA-RELA Fusion Ependymoma | Baylor College of Medicine / Austin Stuckert, MD | Young Investigator Grants | 2021 | Texas |
Characterizing Inflammatory Phenotypes Associated with RUNX1 Deficiency | Dana-Farber Cancer Institute / Waihay Wong, MD/PhD | RUNX1 Early Career Investigator Grants | 2021 | Massachusetts |
Role of PHF6 Mutations in Germline RUNX1 Deficiency Associated Hematopoietic Disorders | The Regents of the University of California San Francisco / Serine Avagyan, MD/PhD | RUNX1 Early Career Investigator Grants | 2021 | California |
Turning Killers into THINKers: TME Hostility-Impervious NK Cells for Treating Neuroblastoma and Sarcoma | Baylor College of Medicine / Robin Parihar, MD/PhD | 'A' Award Grants | 2021 | Texas |
Circulating Tumor Biomarkers: New Paradigms for Management of Neuroblastoma | University of Chicago / Mark Applebaum, PhD | 'A' Award Grants | 2021 | Illinois |
The Interplay Between Histone Mutations and Replication Stress in Shaping Glioma Phenotypes | Dana-Farber Cancer Institute / Pratiti Bandopadhayay, PhD | 'A' Award Grants | 2021 | Massachusetts |
IND-Enabling Studies for WNTinib, a Novel Selective Therapeutic for CTNNB1 Mutant Hepatoblastomas | Icahn School of Medicine at Mount Sinai / Ernesto Guccione, PhD & Josep Llovet, MD & Arvin Dar, PhD | Reach Grants | 2021 | New York |
Optimization of Drug Efflux and Brain Clearance to Improve CED of Targeted Therapy to H3K27M DMG | Mayo Clinic / David Daniels, MD/PhD | Reach Grants | 2021 | Minnesota |
Stapled Peptide PROTAC: A 3-in-1 Treatment for Pediatric Solid Tumors | Dana-Farber Cancer Institute / Loren Walensky, MD/PhD | Reach Grants | 2021 | Massachusetts |
Dual PTK7/GD2 Gamma Delta CAR T Cell Therapy for Neuroblastoma | Emory University / Kelly Goldsmith, MD & H. Trent Spencer, PhD & Chris B. Doering, PhD | Reach Grants | 2021 | Georgia |
Novel Genomic Diagnostics for Intracranial Germ Cell Tumors | Connecticut Children’s Medical Center Foundation, Inc. / Ching Lau, MD/PhD | Reach Grants | 2021 | Connecticut |
Novel targeting approach for pediatric B-cell malignancies | Thomas Jefferson University / Christine Eischen, PhD | Innovation Grants | 2021 | Pennsylvania |
Targeting EZHIP as a therapeutic strategy for infantile ependymomas | University of Wisconsin - Madison / Peter Lewis, PhD | Innovation Grants | 2021 | Wisconsin |
Hematopoietic stem cell function in familial platelet disorder therapy | University of Massachusetts Medical School / Lucio Castilla, PhD | Innovation Grants | 2021 | Massachusetts |
Unraveling metabolic dependencies in childhood supratentorial ependymomas. | Regents of the University of Michigan / Sriram Venneti, MD/PhD | Innovation Grants | 2021 | Michigan |
Role of H3.3-G34R mutation in pediatric high-grade glioma | University of Texas M.D. Anderson Cancer Center / Jian Hu, PhD | Innovation Grants | 2021 | Texas |
Phosphopeptides as shared targets for donor derived T cell therapy of AML | Memorial Sloan-Kettering Cancer Center / Richard O'Reilly, MD | Innovation Grants | 2021 | New York |
A leukemia organoid platform for dissection and targeting of tumor-niche interactions | Columbia Institute for Cancer Genetics / Adolfo Ferrando, MD/PhD | Innovation Grants | 2021 | New York |
Targeting tumor associated macrophages in metastatic Ewing sarcoma (ES) | New York Medical College / Mitchell Cairo, MD | Innovation Grants | 2021 | New York |
Loss of ER-mitochondria contacts drives therapy resistance in neuroblastoma | Children’s Hospital of Philadelphia / Michael Hogarty, MD | Innovation Grants | 2021 | Pennsylvania |
Choline Kinase and Alkylating Agent Resistance in Refractory Childhood Leukemias | Boston Children’s Hospital / Alejandro Gutierrez, MD | Innovation Grants | 2021 | Massachusetts |
In-vivo characterization of MYCN-driven immunosuppression | University of California San Francisco / William Weiss, MD/PhD | Innovation Grants | 2021 | California |
Targeting CCAAT/enhancer binding proteins CEBPB and CEBPD in neuroblastoma | Columbia University / Darrell Yamashiro, MD/PhD | Innovation Grants | 2021 | New York |