Website: ccgresources.org

All resources and references mentioned in this book are available on the website and will be routinely reviewed and updated.

Children’s Oncology Group. (V6, 2023). Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers

Website: www.survivorshipguidelines.org

Clinical trials

Website: https://clinicaltrials.gov

Search, nci-match

Drug development

Website: https://www.fda.gov

Search: drug development approval process, patient focused drug development guidance series

Genetic testing in cancer

Website: https://www.cancer.gov

Search: genetics, genetic testing, causes and preventions

Genetic panels

Website: https://www.chop.edu

Search, cancer-panels

NTRK-fusion positive cancers

Website: https://www.bayer.com

Search: trk-fusion-cancer

US Food and Drug Administration (FDA)

Website: https://www.fda.gov/

Search: patients/drug-development-process, step-3 clinical research

National Cancer Institute–Children’s Oncology Group; Pediatric MATCH Trial (revised June 2023)

Website: https://www.cancer.gov

Search: clinical trials, nci supported, nci match

NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice), also known as Pediatric MATCH, is an international pediatric precision medicine cancer treatment trial that explores whether targeted therapies can be effective for children, adolescents and young adults with solid tumors that harbor specific gene mutations. Pediatric MATCH is a phase 2 trial that investigates different study drugs, each targeting a defined set of gene mutations, in order to match patients with therapies aimed at the molecular abnormalities in his or her tumor.

The Children’s Oncology Group (COG), a National Cancer Institute supported clinical trials group, is the world’s largest organization devoted exclusively to childhood and adolescent cancer research. The COG unites more than 10,000 experts in childhood cancer at more than 200 leading children’s hospitals, universities, and cancer centers across North America, Australia, and New Zealand in the fight against childhood cancer.

Today, more than 90% of 16,000 children and adolescents diagnosed with cancer each year in the United States are cared for at Children’s Oncology Group member institutions. COG’s unparalleled collaborative efforts provide the information and support needed to answer important clinical questions in the fight against cancer.

The Children’s Oncology Group has nearly 100 active clinical trials open at any given time. These trials include front-line treatment for many types of childhood cancers, studies aimed at determining the underlying biology of these diseases, and trials involving new and emerging treatments, supportive care, and survivorship.

The Children’s Oncology Group research has turned children’s cancer from a virtually incurable disease 50 years ago to one with a combined 5-year survival rate of 80% today. Our goal is to cure all children and adolescents with cancer, reduce the short and long-term complications of cancer treatments, and determine the causes and find ways to prevent childhood cancer.