ALSF Childhood Cancer Research Grants
With your support, we have been able to fund outstanding research, leading toward cures and improved quality of life for children with cancer. Browse through more than 1,500 funded projects below.
Use the search tool to refine your results. You can also click on a heading to sort by project title, institution name, or year the grant was awarded. Click on the project title to read more information.
You can learn about ALSF's grant review process here.
ALSF Funded Research Projects
Project Title | Institution / Principal Investigator(s) | Grant Type | Year | State |
---|---|---|---|---|
Preclinical Development of a First-in-Class PCNA Inhibitor for Treating Neuroblastoma | City of Hope National Medical Center / Linda Malkas, PhD | Reach Grants | 2019 | California |
Optimizing TCRαβ+/CD19+-depleted haploidentical HSCT for ALL using donor-derived genome-edited CAR T cells | Stanford University School of Medicine / Alice Bertaina, MD/PhD | Reach Grants | 2019 | California |
Targeting a Novel Epigenetic Signature in Diffuse Intrinsic Pontine Gliomas | New York University School of Medicine / Danny Reinberg, PhD | Reach Grants | 2019 | New York |
Generation of CMV-specific CD19 CAR T cells Using Cytokine Capture Followed by Lentiviral Transduction and Expansion | Research Institute at Nationwide Children's Hospital / Margaret Lamb, MD | Reach Grants | 2019 | Ohio |
Multivalent Nanomedicine to Treat High-Risk Pediatric Solid Tumors | Children’s Hospital of Philadelphia / Garrett Brodeur, MD | Reach Grants | 2019 | Pennsylvania |
Understanding factors contributing to retention in care among children with cancer in sub-Saharan Africa | Baylor College of Medicine / Mark Zobeck, MD, PhD | Psychosocial Launch Grant | 2019 | Texas |
Intervention Development and Evaluation to Reduce Disparities in Quality of Life for Latino Families Impacted by Cancer | The Regents of the University of California, Irvine / Michelle Fortier, PhD | Psychosocial Family Impact Grant | 2019 | California |
Targeting Spinal Ependymoma and Other Gliomas Using Novel Genetically Defined Models | The Johns Hopkins University School of Medicine / Charles Eberhart, MD, PhD | Catalyst Grants | 2019 | Maryland |
Single-cell Profiling of Early T-cell Precursor Acute Lymphoblastic Leukemia | Children’s Hospital of Philadelphia / David Teachey, MD and Kai Tan, PhD | Single-cell Pediatric Cancer Atlas Grant | 2019 | Pennsylvania |
Single-cell Profiling of Pediatric Bone Sarcomas | University of California, Los Angeles / Alice Soragni, PhD | Single-cell Pediatric Cancer Atlas Grant | 2019 | California |
Dissecting Pediatric Brain Tumour Progression Using Single-nuclei Sequencing | University Health Network / Trevor Pugh, PhD | Single-cell Pediatric Cancer Atlas Grant | 2019 | Ontario |
Single Nuclear RNA-seq and Spatial Transcriptomic Analysis of Anaplastic and Favorable Histology Wilms Tumor | St. Jude Children’s Research Hospital / Andrew Murphy, MD and Xiang Chen, PhD | Single-cell Pediatric Cancer Atlas Grant | 2019 | Tennessee |
Single-cell Profiling of Childhood Acute Lymphoblastic Leukemia | St. Jude Children’s Research Hospital / Charles Mullighan, MD and Jeffrey Klco, MD/PhD | Single-cell Pediatric Cancer Atlas Grant | 2019 | Tennessee |
Single Cell RNA Sequencing of Pediatric High- and Low-Grade Gliomas | University of Colorado Denver / Adam Green, MD and Jean Mulcahy Levy, MD | Single-cell Pediatric Cancer Atlas Grant | 2019 | Colorado |
Single-Cell Profiling of Acute Myeloid Leukemia for High-Resolution Chemo-immunotherapy Target Discovery | Stanford University School of Medicine / Charles Gawad, MD/PhD | Single-cell Pediatric Cancer Atlas Grant | 2019 | California |
Profiling the Transcriptional Heterogeneity of Diverse Pediatric Solid Tumors | St. Jude Children’s Research Hospital / Michael Dyer, PhD and Xiang Chen, PhD | Single-cell Pediatric Cancer Atlas Grant | 2019 | Tennessee |
Single-cell Atlas of Pediatric Osteosarcoma | Dana-Farber Cancer Institute / Natalie Collins, MD/PhD | Single-cell Pediatric Cancer Atlas Grant | 2019 | Massachusetts |
Single-cell Gene Expression and Cytosine Modification Profiling in Pediatric Central Nervous System Tumors | Dartmouth College / Brock Christensen, PhD | Single-cell Pediatric Cancer Atlas Grant | 2019 | New Hampshire |
Synergistic Activity of Anti-GD2 Antibody and CD47-Blockade for Immunotherapy of Neuroblastoma and Osteosarcoma | The Board of Trustees of the Leland Stanford Junior University / Robbie Majzner, MD | 'A' Award Grants | 2019 | California |
Elucidating the Role of SETD2 in Pediatric High Grade Glioma Formation | Children’s Hospital of Philadelphia / Thomas De Raedt, PhD | 'A' Award Grants | 2019 | Pennsylvania |
Exploiting the Differentiation Potential of Pediatric High-Grade Glioma to Discover Novel Therapeutic Opportunities | Dana-Farber Cancer Institute / Mariella Filbin, MD/PhD | 'A' Award Grants | 2019 | Massachusetts |
The use of hematopoietic stem and progenitor cells to reverse treatment resistance to PD-1 blockade | University of Florida / Catherine Flores, PhD | Innovation Grants | 2019 | Florida |
Identify Novel Druggable Targets to Treat Philadelphia chromosome-like B-Acute Lymphoblastic Leukemia | Children’s Hospital of Philadelphia / Wei Tong, PhD | Innovation Grants | 2019 | Pennsylvania |
Using Splice Switching Oligonucleotides (SSOs) to target MDM2 for rhabdomyosarcoma therapy | Research Institute at Nationwide Children's Hospital / Dawn Chandler, PhD | Innovation Grants | 2019 | Ohio |
Targeting mechanisms of Siglec15-mediated immune evasion in hematologic malignancies | Emory University / Christopher Porter, MD | Innovation Grants | 2019 | Georgia |
The anti-tumor immune microenvironment in the Sonic Hedgehog subclass of medulloblastoma | Emory University / Anna Kenney, PhD | Innovation Grants | 2019 | Georgia |
Therapeutic Targeting of the Disrupted Metabolic State in DIPG | University of Michigan / Costas Lyssiotis, PhD & Sriram Venneti, MD/PhD | Innovation Grants | 2019 | Michigan |
Norepinephrine Transporter-Targeted Pharmacotherapy of Aggressive Neuroblastoma | Children’s Hospital of Philadelphia / Michael Chorny, PhD | Innovation Grants | 2019 | Pennsylvania |
Targeting microenvironment-induced TGFB signaling to overcome drug resistance in acute lymphoblastic leukemia | St. Jude Children’s Research Hospital / Charles Mullighan, MD | Innovation Grants | 2019 | Tennessee |
Novel Therapy of Heterogeneous B-cell Acute Lymphocytic Leukemia by Targeting Convergent Oncogenic Mediators STATs | University of Alberta / Hasan Uludag, PhD | Innovation Grants | 2019 | Alberta |
Pediatric Osteosarcoma: Identifying the elusive molecular signature and its relationship to this disease | St. Jude Children’s Research Hospital / Linda Hendershot, PhD | Innovation Grants | 2019 | Tennessee |
Saturating CRISPR gene body scans in MLL-rearranged leukemia | Beckman Research Institute of City of Hope / Chun-Wei Chen, PhD | Innovation Grants | 2019 | California |
Role of the macro lncRNA KCNQ1OT1 in embryonal rhabdomyosarcoma tumorigenesis | Duke University / Corinne Linardic, MD/PhD | Innovation Grants | 2019 | North Carolina |
Predicting and Overcoming Resistance to Immunotherapy in Pediatric High-Grade Glioma | Ann & Robert H. Lurie Children’s Hospital of Chicago / Oren Becher, MD & Robert Wechsler-Reya, PhD | Innovation Grants | 2019 | Illinois |
Selectively targeting EP300 with small molecules for neuroblastoma (NB) therapy | Dana-Farber Cancer Institute / Jun Qi, PhD | Innovation Grants | 2019 | Massachusetts |
Epigenetic regulation of genomic instability and its therapeutic implications in T-cell acute lymphoblastic leukemia | Dana-Farber Cancer Institute / Birgit Knoechel, MD/PhD | Innovation Grants | 2019 | Massachusetts |
Targeting symmetric division in pediatric cancers | Dana-Farber Cancer Institute / Rosalind Segal, MD/PhD | Innovation Grants | 2019 | Massachusetts |
Identifying targeted treatments for DICER1-associated sarcomas | Research Institute of the McGill University Health Centre / William Foulkes, MD/PhD & Sidong Huang, PhD | Innovation Grants | 2019 | Quebec |
CD36-Sphingosine 1-Phosphate Axis in Osteosarcoma Progression | Medical University of South Carolina / Meenal Mehrotra, MD/PhD | Innovation Grants | 2019 | South Carolina |
Developing drugs to treat NT5C2 mediated resistance in pediatric ALL | New York University School of Medicine / William Carroll, MD | Innovation Grants | 2019 | New York |
Novel Genomic Drivers in Pediatric Polyposis Syndromes | Children’s Hospital of Philadelphia / Suzanne MacFarland, MD | Young Investigator Grants | 2019 | Pennsylvania |
The Role of Germline Variants in Infant Leukemogenesis | Washington University / Margaret Ferris, MD/PhD | Young Investigator Grants | 2019 | Missouri |
ECM-targeted CAR T-cell therapy for high-grade glioma | St. Jude Children’s Research Hospital / Jessica Wagner, PhD | Young Investigator Grants | 2019 | Tennessee |
Targeted Hyperactivation of PI3K/AKT in B-cell malignancies | Dana-Farber Cancer Institute / Vishal Khairnar, PhD | Young Investigator Grants | 2019 | Massachusetts |
Targeting TGFb Pathway Dependencies in Group 3 Medulloblastoma | University of California San Francisco / Zulekha Qadeer, PhD | Young Investigator Grants | 2019 | California |
Improving CAR T-Cell Therapy for Pediatric Osteosarcoma by Manipulating Arginine Metabolism | St. Jude Children’s Research Hospital / Shannon Lange, PhD | Young Investigator Grants | 2019 | Tennessee |
Identification of Synthetically Immunogenic Compounds to Synergize with Immunotherapy in Neuroblastoma | Children’s Hospital of Philadelphia / Adam Wolpaw, MD/PhD | Young Investigator Grants | 2019 | Pennsylvania |
The Impact Of CD56neg NK Cells in the Pathogenesis of Endemic Burkitt Lymphoma | University of Massachusetts Medical School / Catherine Forconi, PhD | Young Investigator Grants | 2019 | Massachusetts |
Targeting Valine-Specific Amino Acid Dependency -in T-Cell Acute Lymphoblastic Leukemia | New York University School of Medicine / Palaniraja Thandapani, PhD | Young Investigator Grants | 2019 | New York |
Enhancing the therapeutic efficacy of chimeric antigen receptor T cells for acute myeloid leukemia | Washington University / Miriam Kim, MD | Young Investigator Grants | 2019 | Missouri |
Characterization of Chromatin Landscapes to Identify Therapeutic Vulnerabilities in Diffuse Midline Gliomas. | Fred Hutchinson Cancer Research Center / Jay Sarthy, MD/PhD | Young Investigator Grants | 2019 | Washington |
Modeling H3 G34R and BCOR-Altered Glioma Pathogenesis Using Neural Stem Cells | The Johns Hopkins University School of Medicine / Satoshi Nakata, MD/PhD | Young Investigator Grants | 2019 | Maryland |
Kidney Disease after CD19-Targeted Chimeric Antigen Receptor T Cell Therapy for Pediatric Acute Lymphoblastic Leukemia | Children’s Hospital of Philadelphia / Regina Myers, MD | Young Investigator Grants | 2019 | Pennsylvania |
MLL Oncogene-Dependent Enhancer Reprogramming Promotes Leukemogenesis | Stanford University / Feng Pan, PhD | Young Investigator Grants | 2019 | California |
The Role of Tumor Heterogeneity in Relapse of Pediatric Acute Myeloid Leukemia | Children’s Hospital & Research Center at Oakland / Cheryl Peretz, MD | Young Investigator Grants | 2019 | California |
Investigation of Pediatric Rhabdomyosarcoma Recurrence through Single-Cell Sequencing | St. Jude Children’s Research Hospital / Anand Patel, MD/PhD | Young Investigator Grants | 2019 | Tennessee |
Defining the Molecular Mechanisms Underlying Pediatric Brain Tumor Penetrance | Washington University / Nicole Brossier, MD/PhD | Young Investigator Grants | 2019 | Missouri |
Bcl2-Family Inhibitors in Neuroblastoma: Mechanism of Action, Therapy Resistance, and Development of Biomarkers | Children’s Hospital of Philadelphia / Claudia Zapata, MD | Young Investigator Grants | 2019 | Pennsylvania |
Therapeutic Targets and Molecular Mechanisms in Childhood Brainstem Tumors | University Health Network - Toronto Western Research Institute / Jerome Fortin, PhD | Young Investigator Grants | 2019 | Ontario |
Cancer Risk and Incidence in Beckwith-Wiedemann Syndrome | Children’s Hospital of Philadelphia / Jennifer Kalish, MD/PhD | Epidemiology Grants | 2019 | Pennsylvania |
Determining Social Risk Factors for Poor Outcomes in Pediatric Cancer Using Children’s Oncology Group Registries | University of Utah / Anne Kirchhoff, PhD/MPH | Epidemiology Grants | 2019 | Utah |
Investigating phase separated condensates in FPD to MDS/AML progression | Broad Institute / Zuzana Tothova, MD/PhD | RUNX1 Early Career Investigator Grants | 2019 | Massachusetts |
Targeting MYCN | Children’s Hospital of Philadelphia / Yael Mossé, MD & Julie Park, MD | Crazy 8 Pilots | 2019 | Pennsylvania |
Dissecting Microenvironmental Interactions in Pediatric High-Grade Gliomas that Promote Tumor Growth | Dana-Farber Cancer Institute / Mariella G. Filbin, MD/PhD | Crazy 8 Pilots | 2019 | Massachusetts |
Targeting Fusion-driven Sarcomas | National Institutes of Health / Javed Khan, MD | Crazy 8 Pilots | 2019 | Maryland |
A comprehensive public resource for fusion-negative sarcoma sequencing data | University of California San Francisco / Alejandro Sweet-Cordero, MD & Richard Gorlick, MD | Crazy 8 Pilots | 2019 | California |
Live-Cell Surface Proteomic Characterization of Atypical Teratoid Rhabdoid Tumors Using High Throughout Multi-Color Flow | University of Colorado Denver / Siddhartha S. Mitra, PhD | Crazy 8 Pilots | 2019 | Colorado |
Multiplex Ion Beam Imaging of Pediatric Cancers | Stanford University School of Medicine / Crystal L. Mackall, MD | Crazy 8 Pilots | 2019 | California |
Overcoming Obstacles to Drug Development in Pediatric Cancer | Stanford University School of Medicine / Crystal L. Mackall, MD | Crazy 8 Pilots | 2019 | California |
Practical, Reproducible, and Statistically-Rigorous Workflows for Single-Nucleus Analysis of Childhood Cancer Data | Johns Hopkins Bloomberg School of Public Health / Stephanie C. Hicks, PhD | Crazy 8 Pilots | 2019 | Maryland |
Harmonizing Data Sharing Efforts towards a Federated Data Model | University of California at Santa Cruz / Olena M. Vaske, PhD & David Haussler, PhD | Crazy 8 Pilots | 2019 | California |
Platform development for target identification in high risk pediatric leukemias | Columbia University / Adolfo A Ferrando, MD/PhD, Charles Mullighan, MD | Crazy 8 Pilots | 2019 | New York |
Platform development for target identification in high risk pediatric leukemias | St. Jude Children’s Research Hospital / Adolfo A Ferrando, MD/PhD, Charles Mullighan, MD | Crazy 8 Pilots | 2019 | Tennessee |
Targeting the Surface-ome of Embryonal Brain Tumors | Institut Curie / Olivier Ayrault, PhD | Crazy 8 Pilots | 2019 |