ALSF Childhood Cancer Research Grants
With your support, we have been able to fund outstanding research, leading toward cures and improved quality of life for children with cancer. Browse through more than 1,500 funded projects below.
Use the search tool to refine your results. You can also click on a heading to sort by project title, institution name, or year the grant was awarded. Click on the project title to read more information.
You can learn about ALSF's grant review process here.
ALSF Funded Research Projects
| Project Title | Institution / Principal Investigator(s) | Grant Type | Year | State |
|---|---|---|---|---|
| Role of Inflammatory Microenvironment in Clonal evolution and Progression from FPD to AML | Oregon Health & Science University / Anupriya Agarwal, PhD | RARE Grant Program (Research Accelerating RUNX1 Exploration) | 2017 | Oregon |
| Drug Screen for FPD/AML Therapeutics | Children’s Hospital of Philadelphia / Mortimer Poncz, MD | RARE Grant Program (Research Accelerating RUNX1 Exploration) | 2017 | Pennsylvania |
| A Home Physical Activity Program to Improve Cognitive Late Effects in Children Treated with Radiation for Brain Tumors | National Cancer Institute / Pamela Wolters, PhD | Psychosocial Family Impact Grant | 2017 | Maryland |
| Families of Children with Advanced Cancer: Quality of Life & Goals of Care | Research Institute at Nationwide Children's Hospital / Cindy Gerhardt, PhD | Psychosocial Family Impact Grant | 2017 | Ohio |
| Pediatric Precision Oncology: Parent and Adolescent Experiences | Hospital for Sick Children / Anita Villani, MD | Psychosocial Launch Grant | 2017 | Ontario |
| Symptom Burden, Health-Related Quality of Life and Health Care Utilization Among Children Undergoing Hematopoietic Stem Cell Transplantation: Impact of Parent Sleep, Fatigue and Psychological Distress | Children’s Hospital Los Angeles / Jessica Ward, PhD | Nurse Researcher Fellowship Grant | 2017 | California |
| Novel Approaches to AML Differentiation Therapy | Dana-Farber Cancer Institute / Andrew Lane, MD/PhD | 'A' Award Grants | 2017 | Massachusetts |
| Reversing mSWI/SNF (BAF) Complex Misassembly and Genomic Targeting in Human Synovial Sarcoma | Dana-Farber Cancer Institute / Cigall Kadoch, PhD | 'A' Award Grants | 2017 | Massachusetts |
| Therapeutic Targeting of PGBD5-induced DNA Repair Dependency in Pediatric Solid Tumors | Memorial Sloan-Kettering Cancer Center / Alex Kentsis, MD/PhD | Reach Grants | 2017 | New York |
| Targeting Chondroitin Sulphate Proteoglycan 4 (CSPG4) in Glioblastoma | University of North Carolina / Gianpietro Dotti, MD & Barbara Savoldo, MD/PhD | Reach Grants | 2017 | North Carolina |
| Phase I Study of Lentivirus Engineered Autologous AML Cells Expressing IL-12 in Children and Young Adults with Relapsed AML | Children’s Hospital of Wisconsin - Milwaukee / Michael Burke, MD & Jeffrey Medin, MD/PhD | Reach Grants | 2017 | Wisconsin |
| Natural Killer T cells with an IL-15-armored GD2-specific CAR for Children with Neuroblastoma | Baylor College of Medicine / Andras Heczey, MD | Bio-Therapeutic Impact Award | 2017 | Texas |
| Characterization of Novel OTX2-semaphorin Gene Signaling Pathways Regulating the ‘Grow and Go’ Arms of Highly Aggressive Medulloblastomas | University of Manitoba / Tamra Werbowetski-Ogilvie, PhD | Innovation Grants | 2017 | Manitoba |
| Alternative Splicing in the Pathogenesis of Acute Lymphoblastic Leukemia | Children’s Hospital of Philadelphia / Andrei Thomas-Tikhonenko, PhD | Innovation Grants | 2017 | Pennsylvania |
| De-escalation of Radiotherapy for Medulloblastoma by a Novel DNA Damage Checkpoint Inhibitor | Feinstein Institute for Medical Research - North Shore / Marc Symons, PhD | Innovation Grants | 2017 | New York |
| 3-D Printed Self-fitting Shape Memory Bone Grafts for Smart Pediatric Skeletal Reconstruction | University of Massachusetts Medical School / Jie Song, PhD | Innovation Grants | 2017 | Massachusetts |
| Targeted Degradation of Proliferative Transcription Factors in Pediatric Cancers | University of California at Santa Cruz / Seth Rubin, PhD | Innovation Grants | 2017 | California |
| Mechanisms of OTX2 Mediated Chromatin Regulation in Medulloblastoma | Massachusetts General Hospital / Miguel Rivera, MD | Innovation Grants | 2017 | Massachusetts |
| Novel Approaches for Epigenetic Therapy for Relapsed Acute Lymphoblastic Leukemia | The Johns Hopkins University School of Medicine / Linda Resar, MD & Andrei Thomas-Tikhonenko, PhD | Innovation Grants | 2017 | Maryland |
| Establishing the Function of Novel MicroRNAs Associated with Resistance and Relapse in Pediatric AML | Fred Hutchinson Cancer Research Center / Vivian Oehler, MD & Soheil Meshinchi, MD/PhD | Innovation Grants | 2017 | Washington |
| Targeting Childhood Brain Cancer in a Dish to Catalyze New Therapies | University of California, Davis Medical Center / Paul Knoepfler, PhD | Innovation Grants | 2017 | California |
| Role of Protocadherin-9 in Enabling Leukemia Cell Colonization of the CNS | National Jewish Health / Jordan Jacobelli, PhD | Innovation Grants | 2017 | Colorado |
| Development of Mithramycin Analogs for Ewing sarcoma | Van Andel Research Institute / Patrick Grohar, MD/PhD | Innovation Grants | 2017 | Michigan |
| Targeting Metabolic Vulnerabilities in ETP-ALL | Columbia University / Adolfo A. Ferrando, MD/PhD | Innovation Grants | 2017 | New York |
| Defining the Cell Surface Landscape of Diagnostic and Relapsed Neuroblastoma: Immunotherapeutic Target Identification | Children’s Hospital of Philadelphia / Sharon Diskin, PhD | Innovation Grants | 2017 | Pennsylvania |
| Predictive Modeling of MDS Disease Progression From Inherited Bone Marrow Failure Syndrome Using Novel Branching Process and Next Generation Sequencing to Improve Patient-Specific Survival | Cleveland Clinic Foundation / Seth Corey, MD & Marek Kimmel, PhD | Innovation Grants | 2017 | Ohio |
| Genome-Wide 5hmC Profiling of Neuroblastoma Tumors and Patient Cell-Free DNA | University of Chicago / Susan Cohn, MD & Chuan He PhD | Innovation Grants | 2017 | Illinois |
| Targeting Pediatric Brain Tumors Using PTPmu Nanochains with Radiofrequency-Releasable Therapeutics | Case Western Reserve University / Susann Brady-Kalnay, PhD & Efstathios Karathanasis, PhD | Innovation Grants | 2017 | Ohio |
| Development of Nanoparticle-Encapsulated Chemo/Radio-Sensitizers for Intrathecal Delivery | Yale School of Medicine / Ranjit S. Bindra, MD/PhD & Mark Saltzman, PhD | Innovation Grants | 2017 | Connecticut |
| Targeting BRD9 in Sarcoma | Dana-Farber Cancer Institute / Scott Armstrong, MD/PhD | Innovation Grants | 2017 | Massachusetts |
| Long Non-Coding RNAs as Novel Biomarkers and Therapeutic Targets in Pediatric Leukemia | New York University School of Medicine / Iannis Aifantis, PhD | Innovation Grants | 2017 | New York |
| Genomics of Pediatric Germ Cell Tumors | University of Minnesota / Jenny Poynter, PhD | Epidemiology Grants | 2017 | Minnesota |
| Maternal Comorbidities, Pharmaceutical Use and Childhood Cancers: A Record Linkage Study in Taiwan | University of California, Los Angeles / Julia Heck, PhD | Epidemiology Grants | 2017 | California |
| Development and Characterization of Novel Models of Human Osteosarcoma Development and Metastasis | University of Minnesota / Beau Webber, PhD | Young Investigator Grants | 2017 | Minnesota |
| The Impact of Hypoxia on Epigenetic Changes in Neuroblastoma | University of Chicago / Sakshi Uppal, PhD | Young Investigator Grants | 2017 | Illinois |
| Overcoming Glucocorticoid Resistance in Lymphoid Cancers | University of California San Francisco / Anica Wandler, PhD | Young Investigator Grants | 2017 | California |
| High-Throughput Gene-Editing via Microfluidic Cell Deformability to Enable Off-the-Shelf Allogeneic Cellular Immunotherapies | University of California, Los Angeles / Steven Jonas, MD/PhD | Young Investigator Grants | 2017 | California |
| Targeting Glutamine Metabolism in MYC Driven Atypical Teratoid Rhabdoid Tumors | The Johns Hopkins University School of Medicine / Jeffrey Rubens, MD | Young Investigator Grants | 2017 | Maryland |
| Anthracycline-Induced Cardiac Toxicity in Pediatric Acute Myeloid Leukemia | University of Pennsylvania / Kelly Getz, PhD | Young Investigator Grants | 2017 | Pennsylvania |
| Epigenomic Mechanisms of Neuroblastoma Tumorigenesis | Children’s Hospital of Philadelphia / Jo Lynne Harenza, PhD | Young Investigator Grants | 2017 | Pennsylvania |
| Targeting Protein Translation to Antagonize MYC-driven Neuroblastoma | Children’s Hospital of Philadelphia / Andrea Flynn, MD | Young Investigator Grants | 2017 | Pennsylvania |
| Preclinical Efficacy of Daratumumab in T Cell Acute Lymphoblastic Leukemia | New York University School of Medicine / Karen Bride, MD/PhD | Young Investigator Grants | 2017 | New York |
| End-of-Life Care of Children with Cancer: Variation and Stakeholder Priorities | University of Alabama at Birmingham / Emily Johnston, MD | Young Investigator Grants | 2017 | Alabama |
| Identification and Targeting of Microenvironmental Factors Controlling Pediatric Leukemia | New York University School of Medicine / Anastasia Tikhonova, PhD | Young Investigator Grants | 2017 | New York |
| Identification and Characterization of Pathways Dysregulated by MMSET E1099K Mutation in Relapsed Pediatric Acute Lymphoblastic Leukemia and Their Role in Drug Resistance | New York University School of Medicine / Joanna Pierro, DO | Young Investigator Grants | 2017 | New York |
| Elucidating the Role of N-Myc in a High-risk Pediatric T Cell Leukemia | New York University School of Medicine / Francesco Boccalatte, PhD | Young Investigator Grants | 2017 | New York |
| Cancer Susceptibility and Signaling Pathways in Low-Grade Brain Tumors | Jewish General Hospital / Bárbara Rivera, PhD | Young Investigator Grants | 2017 | Quebec |
| Identifying Disease Mechanisms and Therapeutic Opportunities in Pediatric Low-grade Gliomas Driven by MYB-QKI Fusions | Dana-Farber Cancer Institute / Cecile Rouleau, PhD | Young Investigator Grants | 2017 | Massachusetts |
| Development of Novel Biomarkers for Immunotherapy in Neuroblastoma | Columbia Institute for Cancer Genetics / Shuobo Boboila, PhD | Young Investigator Grants | 2017 | New York |
| Understanding the Mechanisms of HOX Gene Regulation in Normal and Leukemic Hematopoietic Stem Cells to Identify New Therapies for Pediatric AML | Boston Children’s Hospital / Anne Robertson, PhD | Young Investigator Grants | 2017 | Massachusetts |
| Role of N6-Methyladenosine (m6A) mRNA Modification Pathway in Neuroblastoma | Boston Children’s Hospital / Shuibin Lin, PhD | Young Investigator Grants | 2017 | Massachusetts |