ALSF Childhood Cancer Research Grants
With your support, we have been able to fund outstanding research, leading toward cures and improved quality of life for children with cancer. Browse through more than 1,500 funded projects below.
Use the search tool to refine your results. You can also click on a heading to sort by project title, institution name, or year the grant was awarded. Click on the project title to read more information.
You can learn about ALSF's grant review process here.
ALSF Funded Research Projects
Project Title | Institution / Principal Investigator(s) | Grant Type | Year | State |
---|---|---|---|---|
Structure-guided de novo design of molecules that selectively target EWS-FLI1 | University of Texas Health Science Center at San Antonio / David Libich, PhD | Innovation Grants | 2023 | Texas |
Synthetic gene expression regulator switches (SynGERS) expressed in CAR T cells to cure children with solid tumors | Baylor College of Medicine / Andras Heczey, MD | R Accelerated Award Grants | 2023 | Texas |
Development of New Approaches to Target MAP Kinase Pathway in RAS-driven Rhabdomyosarcoma | University of Texas Health Science Center at San Antonio / Angelina Vaseva, PhD | R Accelerated Award Grants | 2023 | Texas |
In Situ CD19.CAR-T Generation Using TRIDENT System for Pediatric B Cell Malignancies | Baylor College of Medicine / Masataka Suzuki, PhD | Innovation Grants | 2023 | Texas |
Synthetic Gene Expression Regulatory Switches (SynGERS) for Improved CAR T Cell Function in Pediatric Solid Tumors | Baylor College of Medicine / Leidy Diana Caraballo Galva, PhD | Young Investigator Grants | 2023 | Texas |
GENOME ORIGAMI: Refolding Aberrant Chromosome 3D Structure for Treating NUT Carcinoma | Baylor College of Medicine / Kyle Eagen, PhD | R Accelerated Award Grants | 2022 | Texas |
Function and Dependency of NFkB Activity in ZFTA-RELA Fusion Ependymoma | Baylor College of Medicine / Austin Stuckert, MD | Young Investigator Grants | 2021 | Texas |
Turning Killers into THINKers: TME Hostility-Impervious NK Cells for Treating Neuroblastoma and Sarcoma | Baylor College of Medicine / Robin Parihar, MD/PhD | 'A' Award Grants | 2021 | Texas |
Role of H3.3-G34R mutation in pediatric high-grade glioma | University of Texas M.D. Anderson Cancer Center / Jian Hu, PhD | Innovation Grants | 2021 | Texas |
Using Neurofibromatosis-1 (NF1) to understand Pediatric Brain Tumor Initiation | MD Anderson Cancer Center / Yuan Pan, PhD | Young Investigator Grants | 2020 | Texas |
High-throughput CAR NKT Library Screen for Improving Neuroblastoma Immunotherapy | Baylor College of Medicine / Xavier Rios, MD/PhD | Young Investigator Grants | 2020 | Texas |
Understanding factors contributing to retention in care among children with cancer in sub-Saharan Africa | Baylor College of Medicine / Mark Zobeck, MD, PhD | Psychosocial Launch Grant | 2019 | Texas |
The Role of Pyruvate Dehydrogenase in Leukemia | University of Texas Southwestern Medical Center at Dallas / Michalis Agathocleous, PhD | 'A' Award Grants | 2018 | Texas |
RNA Methylation in Metabolically Disrupted Pediatric Cancers | University of Texas Health Science Center at San Antonio / Patricia Dahia, MD/PhD | Innovation Grants | 2018 | Texas |
Modeling and Therapeutic Targeting of p21-Activated Kinase Members in High-Risk Rhabdomyosarcoma | Baylor College of Medicine / Jason Yustein, MD/PhD | Innovation Grants | 2018 | Texas |
Energy Balance Strategies for Decreasing Chemotherapy-Induced Cardiotoxicity | University of Texas M.D. Anderson Cancer Center / Eugenie Kleinerman, MD | Innovation Grants | 2018 | Texas |
Natural Killer T cells with an IL-15-armored GD2-specific CAR for Children with Neuroblastoma | Baylor College of Medicine / Andras Heczey, MD | Bio-Therapeutic Impact Award | 2017 | Texas |
Role of Primary Cilium Signaling and Dynamics in Medulloblastoma Initiation and Progression | University of Texas Southwestern Medical Center / Saikat Mukhopadhyay, MD/PhD | 'A' Award Grants | 2016 | Texas |
Engineering the CAR T Cells to Overcome Tumor Derived Immune-Inhibition in Glioblastoma | Baylor College of Medicine / Meenakshi Hegde, MD | 'A' Award Grants | 2016 | Texas |
Targeting PLK1 as a Common Mechanism in Ph-like ALL | University of Texas M.D. Anderson Cancer Center / Joya Chandra, PhD | Reach Grants | 2016 | Texas |
DICER1-Driven Cancers: Models, Mechanisms and Therapies | University of Texas Southwestern Medical Center at Dallas / James Amatruda, MD/PhD | Innovation Grants | 2016 | Texas |
Targeting MYCN-amplified Neuroblastoma Through RORalpha Activation | Baylor College of Medicine / Eveline Barbiere, MD | Innovation Grants | 2016 | Texas |
Interrogating the Enhancer Landscapes of Ependymoma to Inform Novel Therapies | Baylor College of Medicine / Stephen Mack, PhD | Young Investigator Grants | 2016 | Texas |
Genetically Engineered T Cells as Therapy for Pediatric Glioma | Baylor College of Medicine / Giedre Krenciute, PhD | Young Investigator Grants | 2016 | Texas |
The Role of MiRNA Impairment in Wilms' Tumor Formation | University of Texas Southwestern Medical Center at Dallas / Kenneth Chen, MD | Young Investigator Grants | 2016 | Texas |
Enhancing the Viability, Function, and Safety, of Genetically-Enhanced NK Cells Within the Solid Tumor Microenvironment With IL-15 and a Suicide Gene | Baylor College of Medicine / Robin Parihar, MD, PhD | Young Investigator Grants | 2015 | Texas |
Zebrafish Modeling of PAX3-FOXO1 Driven Rhabdomyosarcoma | University of Texas Southwestern Medical Center / Genevieve Kendall, PhD | Young Investigator Grants | 2015 | Texas |
Elucidating the Mechanism of ERK Mediated Pathogenesis of LCH | Baylor College of Medicine / Rikhia Chakraborty, PhD | Young Investigator Grants | 2015 | Texas |
Cell Line and Xenograft Repository | Texas Tech University Health Sciences Center / Patrick Reynolds, MD/PhD | Catalyst Grants | 2014 | Texas |
Immunotherapy of Neuroblastoma with CAR.GD2 NKT Cells | Baylor College of Medicine / Leonid S. Metelitsa, M.D., Ph.D. | Bio-Therapeutic Impact Award | 2014 | Texas |
Two-pronged Cell Therapy: Engineering T Cells to Redirect Bystander T- and NK-Cells to Pediatric Cancer | Baylor College of Medicine / Stephen Gottschalk, M.D. | Innovation Grants | 2014 | Texas |
STAT3 Signaling Profiles Predict Response to Chemotherapy in Pediatric AML | Baylor College of Medicine / Michele Redell, M.D./Ph.D. | Springboard Grants | 2014 | Texas |
Optimizing Engager T-cells for CD19+ Malignancies | Baylor College of Medicine / Mireya Paulina Velasquez, MD | Young Investigator Grants | 2014 | Texas |
Immunotherapy Of Neuroblastoma With Natural Killer T Cells Engineered To Target O-acetyl-GD2 | Baylor College of Medicine / Andras Heczey, MD | Young Investigator Grants | 2014 | Texas |
Exploring the Intersection between Childhood Cancer and Birth Defects to Identify Novel Cancer Predisposition Syndromes | Baylor College of Medicine / Philip Lupo, PhD | Epidemiology Grants | 2014 | Texas |
Immunotherapy for Pediatric Atypical Teratoid/Rhabdoid Tumor | Baylor College of Medicine / William Decker, PhD | Reach Grants | 2013 | Texas |
B-lapachone as a Novel Targeted Therapy for ATRTs and other Pediatric Cancers | University of Texas Southwestern Medical Center / James Amatruda, MD, PhD | Reach Grants | 2013 | Texas |
Combining Oncolytic Vaccinia Virus with GD2.CAR-modified Vaccinia Virus-specific T-cells for the Treatment of Relapsed Neuroblastoma and Sarcoma | Baylor College of Medicine / Cliona Rooney, PhD | Reach Grants | 2013 | Texas |
Engager T cells for the Adoptive Immunotherapy of Pediatric Malignancies | Baylor College of Medicine / Stephen Gottschalk, MD | Innovation Grants | 2013 | Texas |
Multispecific T Cells for Adoptive Immunotherapy of Pediatric High Grade Glioma (HGG) | Baylor College of Medicine / Nabil Ahmed, MD, MSc | Innovation Grants | 2013 | Texas |
Pre-Clinical Testing of T cells Coded with CARs for DIPG | University of Texas / Laurence Cooper, MD, PhD | Innovation Grants | 2013 | Texas |
Dissecting and Targeting the Wnt Signaling Pathway in Metastatic Osteosarcoma | Baylor College of Medicine / Jason T. Yustein, MD, PhD | Young Investigator Grants | 2013 | Texas |
Texas Children's Cancer Center Alex's Lemonade Stand Center of Excellence | Baylor College of Medicine / Stacey Berg, MD - Scholars: Holly Lindsay, MD/MS, Sarah Injac, MD | Center of Excellence Grants | 2012 | Texas |
Adoptive Cell Therapy Targeting Antigen Escape Variants in Childhood High Grade Glioma | Baylor College of Medicine / Meenakshi Hegde | Young Investigator Grants | 2012 | Texas |
Screening for New Rhabdomyosaroma Pathogenesis Genes in a Drosophila Model | University of Texas Southwestern Medical Center / Kathleen Galindo | Young Investigator Grants | 2012 | Texas |
V alpha-invariant NKT cells as a novel platform for cancer immunotherapy | Baylor College of Medicine / Leonid Metelitsa, MD, PhD | Innovation Grants | 2012 | Texas |
Mechanisms of LYL1-associated T-ALL development | Baylor College of Medicine / Margaret Goodell, PhD | Innovation Grants | 2012 | Texas |
Strategies for Epigenetically Reprogramming Neuroblastoma Cancer Stem Cells | Baylor College of Medicine / Jason Shohet, MD, PhD | Innovation Grants | 2011 | Texas |
Validation of microRNAs as valid targets in a pediatric sarcoma | University of Texas Southwestern Medical Center / Mark Hatley | Young Investigator Grants | 2011 | Texas |
Telomeres and Telomerase in Pediatric Acute Myeloid Leukemia | Baylor College of Medicine / Maria Gramatges | Young Investigator Grants | 2011 | Texas |
Pediatric Sarcoma, Rhabdomyosarcoma, and Mechanisms of Origin | University of Texas Southwestern Medical Center / Rene Galindo | 'A' Award Grants | 2010 | Texas |
Understanding the Role of a Novel Hereditary Cancer Gene | University of Texas Health Science Center at San Antonio / Patricia Dahia | Innovation Grants | 2010 | Texas |
Center for Pediatric T Cell Therapy (CEPET) | Baylor College of Medicine / Cliona Rooney | Phase I/II Infrastructure Grants | 2010 | Texas |
Genetic Analysis of Pediatric Gliomas | Baylor College of Medicine / Will Parsons, MD, PhD | 'A' Award Grants | 2009 | Texas |
Fatigue and Carnitine Levels over Eight Cycles of Chemotherapy in Children and Adolescents. | Baylor College of Medicine / Marilyn Hockenberry | Nurse Researcher Grants | 2008 | Texas |
Characterization and Targeting of p53 Ubiquitination in Neuroblastoma. | Baylor College of Medicine / Eveline Barbieri, MD, PhD | Young Investigator Grants | 2008 | Texas |
Treatment of high-risk pediatric brain tumors with a CD133-targeted adenovirus in combination with temozolomide | University of Texas M.D. Anderson Cancer Center / Marta Alonso, PhD | Young Investigator Grants | 2008 | Texas |
Parallel sequencing to identify the causes of childhood cancer | Baylor College of Medicine / Sharon Plon | Innovation Grants | 2008 | Texas |
The Meaning of Adolescents' Eating Experiences during Bone Marrow Transplant Recovery. | Baylor College of Medicine / Cheryl Rodgers, PhD, RN | Nurse Researcher Grants | 2007 | Texas |
Adoptive immunotherapy using clinical-grade T cells. | University of Texas M.D. Anderson Cancer Center / Laurence Cooper, MD, PhD | Innovation Grants | 2007 | Texas |
Immunotherapy for Osteosarcoma and Ewing sarcoma | Baylor College of Medicine / Nabil Ahmed, MD, MSc | Young Investigator Grants | 2007 | Texas |
Parallel sequencing to identify the causes of childhood cancer. | Baylor College of Medicine / Sharon Plon, MD, PhD | Innovation Grants | 2006 | Texas |
Building a Texas-based center for neuroblastoma clinical research. | Baylor College of Medicine / Heidi Russell, MD | Phase I/II Infrastructure Grants | 2006 | Texas |
Mediators of Metastasis in Alveolar Rhabdomyosarcoma. | University of Texas Health Science Center at San Antonio / Koichi Nishijo, MD, PhD | Young Investigator Grants | 2006 | Texas |